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Hydrodynamic effect on cell attachment to microcarriers at initial stage of microcarrier culture

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Abstract

An effect of intermittent agitation on cell attachment is studied. The result of cell attachment to a microcarrier was best in the case of continuous agitation. All cells attached to microcarriers under the condition of continuous agitation for 60 min. The rate of attachment was also the highest. The positive effect on cell attachment by agitation is due to the wake around the microcarrier and some changes of structure of cell membrane.

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Authors and Affiliations

  1. Department of Biological and Chemical Engineering, Gunma University, 1–5–1 Tenjin-cho, Kiryu, Gunma, Japan, , , , , , JP

    N. Shiragami, M. Hakoda & A. Enomoto

  2. Center for Cooperative Research, Gunma University, 1–5–1 Tenjin-cho, Kiryu, Gunma, Japan, , , , , , JP

    T. Hoshino

Authors
  1. N. Shiragami
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  2. M. Hakoda
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  3. A. Enomoto
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  4. T. Hoshino
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Received: 12 August 1996

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Shiragami, N., Hakoda, M., Enomoto, A. et al. Hydrodynamic effect on cell attachment to microcarriers at initial stage of microcarrier culture. Bioprocess Engineering 16, 399–401 (1997). https://doi.org/10.1007/s004490050343

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  • DOI: https://doi.org/10.1007/s004490050343

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