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Biogenic synthesis of dopamine/carboxymethyl cellulose/TiO2 nanoparticles using Psidium guajava leaf extract with enhanced antimicrobial and anticancer activities

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Abstract

The green synthesis of metal oxide nanoparticles (NPs) has garnered considerable attention from researchers due to its utilization of eco-friendly solvents during synthesis and cost-effective approaches. This study focuses on the synthesis of titanium oxide (TiO2) and dopamine (DA) carboxymethyl cellulose (CMC)-doped TiO2 (DA/CMC/TiO2) NP using Psidium guajava leaf extract, while also investigating the structural, optical, and morphological and biocidal potential of the prepared NPs. Significantly larger zones of inhibition were observed for DA/CMC/TiO2 NPs compared to TiO2 against various pathogens. Moreover, the MTT assay was carried out to evaluate the anticancer activity of the prepared samples against MG-63 cells, and the results revealed that DA/CMC/TiO2 NPs exhibited significantly higher level of anticancer activity compared to TiO2. The experimental results demonstrated that DA/CMC/TiO2 NPs exhibited enhanced anticancer activity in a dose-dependent manner when compared to TiO2 NPs.

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The authors declare that all the data supporting the findings of this study are available within the article.

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Funding

The authors extend their appreciation to the Researchers Supporting Project number (RSPD2023R677), King Saud University, Riyadh, Saudi Arabia for financial support.

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Authors and Affiliations

  1. Department of Biotechnology, School of Sciences, Jain (Deemed-to-be University), Bangalore, 560027, India

    Kavina Ganapathy

  2. College of Pharmacy, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh, 244001, India

    Vaibhav Rastogi

  3. Department of Chemistry, Vivekananda Global University, Jaipur, Rajasthan, 303012, India

    Chandra Prakash Lora

  4. Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and Devices, School of Information and Optoelectronic Science and Engineering, South China Normal University, Guangzhou, 510006, China

    Jagadeesh Suriyaprakash

  5. Department of Botany and Microbiology, College of Science, King Saud University, P. O. Box.2455, 11451, Riyadh, Saudi Arabia

    Abdullah A. Alarfaj & Abdurahman Hajinur Hirad

  6. Department of Chemistry, CHRIST (Deemed to be University), Bangalore, 560029, India

    T. Indumathi

Authors
  1. Kavina Ganapathy
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  2. Vaibhav Rastogi
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  3. Chandra Prakash Lora
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  4. Jagadeesh Suriyaprakash
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  5. Abdullah A. Alarfaj
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  6. Abdurahman Hajinur Hirad
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  7. T. Indumathi
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Contributions

KG: Conceptualization, Methodology, Software. VR: Data curation, Writing- Original draft preparation. CPL: Visualization, Investigation. JS: Supervision. AAA and AHH: Software, Validation. IT: Writing- Reviewing and Editing.

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Correspondence to T. Indumathi.

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Ganapathy, K., Rastogi, V., Lora, C.P. et al. Biogenic synthesis of dopamine/carboxymethyl cellulose/TiO2 nanoparticles using Psidium guajava leaf extract with enhanced antimicrobial and anticancer activities. Bioprocess Biosyst Eng 47, 131–143 (2024). https://doi.org/10.1007/s00449-023-02954-6

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  • DOI: https://doi.org/10.1007/s00449-023-02954-6

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