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Biofabrication of Mg-doped ZnO nanostructures for hemolysis and antibacterial properties

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Abstract

The aim of this work was to synthesize 0.02 and 0.06 Mg-doped ZnO nanoparticles (NPs) using the aqueous extract of Plectranthus barbatus leaf. The structural integrity of the hexagonal phase was emphasized by X-ray diffraction analysis. The average crystallite size (D) of 0.02 and 0.06 Mg-doped ZnO NPs was found to be 23.83 and 26.95 nm, respectively. The scanning electron microscope images revealed a surface morphology of irregular nano-shapes of about 83 nm diameter with an elongated one-dimensional structure. The hemolysis activity demonstrated the safe nature of the synthesized materials at low doses. Antibacterial activity against S. aureus and E. coli, which assessed using the disc diffusion method, indicated that the prepared NPs could inhibit S. aureus but not E. coli. These findings suggest that the synthesized NPs could be explored for potential applications in biotechnology and medicine.

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Data availability

The data sets generated and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

The authors extend their appreciation to the Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia for funding this research (IFKSURC-1-1909).

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Authors and Affiliations

  1. Engineer Abdullah Bugshan Research Chair for Dental and Oral Rehabilitation, College of Dentistry, King Saud University, 11545, Riyadh, Saudi Arabia

    Abdel-Basit Al-Odayni & Waseem Sharaf Saeed

  2. Department of Physics, Faculty of Sciences, Sana’a University, Sana’a, Yemen

    Adnan Alnehia & A. H. Al-Hammadi

  3. Department of Physics, Faculty of Applied Sciences, Thamar University, 87246, Dhamar, Yemen

    Adnan Alnehia & Annas Al-Sharabi

  4. Department of Chemistry, College of Science, King Saud University, 11451, Riyadh, Saudi Arabia

    Naaser A. Y. Abduh

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  1. Abdel-Basit Al-Odayni
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  2. Adnan Alnehia
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  4. A. H. Al-Hammadi
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  5. Waseem Sharaf Saeed
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  6. Naaser A. Y. Abduh
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Correspondence to Adnan Alnehia.

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Al-Odayni, AB., Alnehia, A., Al-Sharabi, A. et al. Biofabrication of Mg-doped ZnO nanostructures for hemolysis and antibacterial properties. Bioprocess Biosyst Eng 46, 1817–1824 (2023). https://doi.org/10.1007/s00449-023-02937-7

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