Skip to main content
SpringerLink
Log in

Electrochemical sensor for sensitive detection of paracetamol based on novel multi-walled carbon nanotubes-derived organic–inorganic material

  • Original Paper
  • Published:
Bioprocess and Biosystems Engineering Aims and scope Submit manuscript

Abstract

A new electrochemical sensor based on a novel organic–inorganic material (PNFCTs) was proposed for detection of paracetamol in this paper. First, PNFCTs were prepared with multi-walled carbon nanotubes (MWNTs) and a derivative of 3,4,9,10-perylenetetracarboxylic dianhydride (PTC-NH2) via cross-linking method. Then, PNFCTs were coated onto the surface of the glassy carbon electrode (GCE) to form porous organic conducting polymer films (PNFCTs/GCE), which could not only increase the loading of paracetamol efficiently but also provide an interface with exceptional electrical conductivity for paracetamol. Finally, gold nanoparticles (GNPs) were attached to the electrode surface through electrodepositing method, which obtained GNPs/PNFCTs/GCE electrode. The electrochemical behavior of paracetamol on GNPs/PNFCTs/GCE was explored by cyclic voltammetrys (CVs) and differential pulse voltammograms (DPVs). The results showed that the GNPs/PNFCTs/GCE exhibited excellent electrocatalytic activity to paracetamol, which should be attributed to remarkable properties of the new composite nanomaterials with porous nanostructure and exceptional electrical conductivity. The wide liner range and detection limit were 0.3–575 and 0.1 μM, respectively. Finally, it was successfully used to detect paracetamol in dilution human serum and commercial tablets. The sensor shows great promise for simple, sensitive, and selective detection paracetamol and provides a promising approach in paracetamol clinical research and overdose diagnostic applications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Scheme 1
Fig. 5
Fig. 6

Similar content being viewed by others

References

  1. Dogrul A, Seyrek M, Akgul EO, Cayci T, Kahraman S, Bolay H (2012) Systemic paracetamol-induced analgesic and antihyperalgesic effects through activation of descending serotonergic pathways involving spinal 5-HT7 receptors. Eur J Pharmacol 677:93–101

    Article  CAS  Google Scholar 

  2. Miranda HF, Noriega V, Prieto JC (2012) Previous administration of naltrexone did not change synergism between paracetamol and tramadol in mice. Pharmacol Biochem Behav 102:72–76

    Article  CAS  Google Scholar 

  3. Kachoosangi RT, Wildgoose GG, Compton RG (2008) Sensitive adsorptive stripping voltammetric determination of paracetamol at multiwalled carbon nanotube modified basal plane pyrolytic graphite electrode. Anal Chim Acta 618:54–60

    Article  CAS  Google Scholar 

  4. Iqbal M, Cash WJ, Sarwar S, McCormick PA (2012) Paracetamol overdose: the liver unit perspective. Ir J Med Sci 181:439–443

    Article  CAS  Google Scholar 

  5. Goyal RN, Rana AR, Aziz MA, Oyama M (2011) Effect of gold nanoparticle attached multi-walled carbon nanotube-layered indium tin oxide in monitoring the effect of paracetamol on the release of epinephrine. Anal Chim Acta 693:35–40

    Article  CAS  Google Scholar 

  6. Fan Y, Liu J-H, Lu H-T, Zhang Q (2011) Electrochemical behavior and voltammetric determination of paracetamol on Nafion/TiO2–graphene modified glassy carbon electrode. Colloids Surf B 85:289–292

    Article  CAS  Google Scholar 

  7. Goyal RN, Gupta VK, Chatterjee S (2010) Voltammetric biosensors for the determination of paracetamol at carbon nanotube modified pyrolytic graphite electrode. Sens Actuators B 149:252–258

    Article  CAS  Google Scholar 

  8. Raoof JB, Baghayeri M, Ojani R (2012) A high sensitive voltammetric sensor for qualitative and quantitative determination of phenobarbital as an antiepileptic drug in presence of acetaminophen. Colloids Surf B 95:121–128

    Article  CAS  Google Scholar 

  9. Li C, Martin BC (2011) Trends in emergency department visits attributable to acetaminophen overdoses in the United States: 1993–2007. Pharmacoepidemiol Drug Saf 20:810–818

    Article  Google Scholar 

  10. Gosselin S, Hoffman RS, Juurlink DN, Whyte I, Yarema M, Caro J (2013) Treating acetaminophen overdose: thresholds, costs and uncertainties. Clin Toxicol (Phila) 51:130–133

    Article  CAS  Google Scholar 

  11. Roy J, Saha P, Sultana S, Kenyon AS (1997) Rapid screening of marketed paracetamol tablets: use of thin-layer chromatography and a semiquantitative spot test. Bull World Health Organ 75:19–22

    CAS  Google Scholar 

  12. Jensen LS, Valentine J, Milne RW, Evans AM (2004) The quantification of paracetamol, paracetamol glucuronide and paracetamol sulphate in plasma and urine using a single high-performance liquid chromatography assay. J Pharm Biomed Anal 34:585–593

    Article  CAS  Google Scholar 

  13. Nebot C, Gibb SW, Boyd KG (2007) Quantification of human pharmaceuticals in water samples by high performance liquid chromatography–tandem mass spectrometry. Anal Chim Acta 598:87–94

    Article  CAS  Google Scholar 

  14. Baranowska I, Markowski P, Baranowski J (2006) Simultaneous determination of 11 drugs belonging to four different groups in human urine samples by reversed-phase high-performance liquid chromatography method. Anal Chim Acta 570:46–58

    Article  CAS  Google Scholar 

  15. Speed DJ, Dickson SJ, Cairns ER, Kim ND (2001) Analysis of paracetamol using solid-phase extraction, deuterated internal standards, and gas chromatography–mass spectrometry. J Anal Toxicol 25:198–202

    Article  CAS  Google Scholar 

  16. Kumar Talluri MVN, Bairwa MK, Theja Dugga HH, Srinivas R (2012) Development and validation of RP-HPLC and ultraviolet spectrophotometric methods of analysis for simultaneous determination of paracetamol and lornoxicam in pharmaceutical dosage forms. J Liq Chromatogr Relat Technol 35:129–140

    Article  CAS  Google Scholar 

  17. Kang X, Wang J, Wu H, Liu J, Aksay IA, Lin Y (2010) A graphene-based electrochemical sensor for sensitive detection of paracetamol. Talanta 81:754–759

    Article  CAS  Google Scholar 

  18. Chen X, Zhu J, Xi Q, Yang W (2012) A high performance electrochemical sensor for acetaminophen based on single-walled carbon nanotube–graphene nanosheet hybrid films. Sens Actuators B 161:648–654

    Article  CAS  Google Scholar 

  19. Veetil JV, Ye K (2007) Development of immunosensors using carbon nanotubes. Biotechnol Prog 23:517–531

    Article  CAS  Google Scholar 

  20. Choi HN, Lee J-Y, Lyu Y-K, Lee W-Y (2006) Tris(2,2′-bipyridyl)ruthenium(II) electrogenerated chemiluminescence sensor based on carbon nantube dispersed in sol–gel-derived titania–nafion composite films. Anal Chim Acta 565:48–55

    Article  CAS  Google Scholar 

  21. Duan LS, Xie F, Zhou F, Wang SF (2007) The electrochemical behavior of acetaminophen on multi-walled carbon nanotubes modified electrode and its analytical application. Anal Lett 40:2653–2663

    Article  CAS  Google Scholar 

  22. Babaei A, Afrasiabi M, Babazadeh M (2010) A glassy carbon electrode modified with multiwalled carbon nanotube/chitosan composite as a new sensor for simultaneous determination of acetaminophen and mefenamic acid in pharmaceutical preparations and biological samples. Electroanalysis 22:1743–1749

    Article  CAS  Google Scholar 

  23. Wan Q, Wang X, Yu F, Wang X, Yang N (2009) Effects of capacitance and resistance of MWNT-film coated electrodes on voltammetric detection of acetaminophen. J Appl Electrochem 39:1145–1151

    Article  CAS  Google Scholar 

  24. Bui M-PN, Li CA, Han KN, Pham X-H, Seong GH (2012) Determination of acetaminophen by electrochemical co-deposition of glutamic acid and gold nanoparticles. Sens Actuators B 174:318–324

    Article  CAS  Google Scholar 

  25. Babaei A, Garrett DJ, Downard AJ (2011) Selective simultaneous determination of paracetamol and uric acid using a glassy carbon electrode modified with multiwalled carbon nanotube/chitosan composite. Electroanalysis 23:417–423

    Article  CAS  Google Scholar 

  26. Yuan Y, Gou X, Yuan R, Chai Y, Zhuo Y, Ye X, Gan X (2011) Graphene-promoted 3,4,9,10-perylenetetracarboxylic acid nanocomposite as redox probe in label-free electrochemical aptasensor. Biosens Bioelectron 30:123–127

    Article  CAS  Google Scholar 

  27. Zhuo Y, Yuan P-X, Yuan R, Chai Y-Q, Hong C-L (2008) Nanostructured conductive material containing ferrocenyl for reagentless amperometric immunosensors. Biomaterials 29:1501–1508

    Article  CAS  Google Scholar 

  28. Peng K, Zhao H, Wu X, Yuan Y, Yuan R (2012) Ultrasensitive aptasensor based on graphene-3,4,9,10-perylenetetracarboxylic dianhydride as platform and functionalized hollow PtCo nanochains as enhancers. Sens Actuators B 169:88–95

    Article  CAS  Google Scholar 

  29. Li W, Yuan R, Chai Y, Hong C, Zhuo Y (2008) Reagentless electrochemical hydrogen peroxide biosensor based on toluidine blue-derived organic material and functionalized gold nanoparticles. J Electrochem Soc 155:F97–F103

    Article  CAS  Google Scholar 

  30. Li W, Yuan R, Chai Y (2010) Determination of glucose using pseudobienzyme channeling based on sugar–lectin biospecific interactions in a novel organic–inorganic composite matrix. J Phys Chem C 114:21397–21404

    Article  CAS  Google Scholar 

  31. Satishkumar BC, Govindaraj A, Mofokeng J, Subbanna GN, Rao CNR (1996) Novel experiments with carbon nanotubes: opening, filling, closing and functionalizing nanotubes. J Phys B: At Mol Opt Phys 29:4925–4934

    Article  CAS  Google Scholar 

  32. Kachoosangi RT, Wildgoose GG, Compton RG (2008) Sensitive adsorptive stripping voltammetric determination of paracetamol at multiwalled carbon nanotube modified basal plane pyrolytic graphite electrode. Anal Chim Acta 618:54–60

    Article  CAS  Google Scholar 

  33. Shangguan X, Zheng J (2009) Direct electron transfer and electrocatalysis of myoglobin based on its direct immobilization on carbon ionic liquid electrode. Electroanalysis 21:881–886

    Article  CAS  Google Scholar 

  34. Laviron E (1979) General expression of the linear potential sweep voltammogram in the case of diffusionless electrochemical systems. J Electroanal Chem 101:19–28

    Article  CAS  Google Scholar 

  35. Nematollahi D, Shayani-Jam H, Alimoradi M, Niroomand S (2009) Electrochemical oxidation of acetaminophen in aqueous solutions: kinetic evaluation of hydrolysis, hydroxylation and dimerization processes. Electrochim Acta 54:7407–7415

    Article  CAS  Google Scholar 

  36. ICH (1994) Validation of a analytical procedures: text and methodology Q2(R1). http://www.ich.org/products/guidelines/quality/article/quality-guidelines.html. Accessed 5 May 2013

Download references

Acknowledgments

This work was supported by Major National Science and Technology Projects of China (2010ZX09401-306-1-1), the NNSF of China (21205146), and science and technology innovation ability of construction projects of Chongqing (CSTC, 2010AA5058).

Author information

Authors and Affiliations

  1. Institute of Life Science, Chongqing Medical University, Chongqing, 400016, People’s Republic of China

    Junmin Hui, Wenjuan Li, Yanlei Guo, Zhu Yang, Yingxiong Wang & Chao Yu

Authors
  1. Junmin Hui
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wenjuan Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yanlei Guo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Zhu Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yingxiong Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Chao Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chao Yu.

Additional information

J. Hui and W. Li contributed equally to this work.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (DOC 723 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hui, J., Li, W., Guo, Y. et al. Electrochemical sensor for sensitive detection of paracetamol based on novel multi-walled carbon nanotubes-derived organic–inorganic material. Bioprocess Biosyst Eng 37, 461–468 (2014). https://doi.org/10.1007/s00449-013-1013-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00449-013-1013-4

Keywords

Search

Navigation