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Penicillin acylase catalysis in the presence of ionic liquids

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Abstract

Several ionic liquids were used as reaction media for penicillin G acylase catalysis. In all the assayed ionic liquids, [bmim]PF6 proved good media for PGA-catalyzed hydrolysis. A novel [bmim]PF6/water two-phase system is provided for 6-aminopenicillanic acid (APA) production, which will be more benefical than aquous batch systems used widely in industrial production of APA.

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Authors and Affiliations

  1. State Key Laboratory of Bioreactor Engineering, Institute of New World Biotechnology, East China University of Science and Technology, Shanghai, 200237, China

    Wei-Guo Zhang, Dong-Zhi Wei, Xue-Peng Yang & Qing-Xun Song

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  1. Wei-Guo Zhang
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  2. Dong-Zhi Wei
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  3. Xue-Peng Yang
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  4. Qing-Xun Song
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Correspondence to Dong-Zhi Wei.

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Zhang, WG., Wei, DZ., Yang, XP. et al. Penicillin acylase catalysis in the presence of ionic liquids. Bioprocess Biosyst Eng 29, 379–383 (2006). https://doi.org/10.1007/s00449-006-0085-9

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  • DOI: https://doi.org/10.1007/s00449-006-0085-9

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