Skip to main content
Log in

Gli genes and limb development

  • Published:
Cell and Tissue Research Aims and scope Submit manuscript


During development of the limb Shh plays a key role as a mediator of zone of polarizing activity (ZPA). However, the molecular mechanisms by which Shh directs anterior/posterior patterning in the limb remain unknown. Members of the Gli gene family encode zinc-finger transcription factors and represent likely candidates for being regulators of Shh target genes. In this review we would like to summarize the current knowledge on expression and function of Gli genes in limb development.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations


Additional information

Received: 31 August 1998 / Accepted: 22 October 1998

Rights and permissions

Reprints and permissions

About this article

Cite this article

Theil, T., Kaesler, S., Grotewold, L. et al. Gli genes and limb development. Cell Tissue Res 296, 75–83 (1999).

Download citation

  • Issue Date:

  • DOI: