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Gli genes and limb development

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Abstract

During development of the limb Shh plays a key role as a mediator of zone of polarizing activity (ZPA). However, the molecular mechanisms by which Shh directs anterior/posterior patterning in the limb remain unknown. Members of the Gli gene family encode zinc-finger transcription factors and represent likely candidates for being regulators of Shh target genes. In this review we would like to summarize the current knowledge on expression and function of Gli genes in limb development.

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Authors and Affiliations

  1. Institut für Molekularbiologie, Medizinische Hochschule Hannover, OE 5250, D-30623 Hannover, Germany e-mail: urue@ifm.mh-hannover.de Tel.: +49 511 532 4017; Fax: +49 511 532 4283, , , , , , DE

    Thomas Theil, Susanne Kaesler, Lars Grotewold, Jens Böse & U. Rüther

Authors
  1. Thomas Theil
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  2. Susanne Kaesler
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  3. Lars Grotewold
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  4. Jens Böse
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  5. U. Rüther
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Received: 31 August 1998 / Accepted: 22 October 1998

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Theil, T., Kaesler, S., Grotewold, L. et al. Gli genes and limb development. Cell Tissue Res 296, 75–83 (1999). https://doi.org/10.1007/s004410051268

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  • DOI: https://doi.org/10.1007/s004410051268

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