Abstract.
Age-related decline of the thymus in ICR female mice was studied following long-term (three month) weekly exposure to hydrocortisone acetate. When examined one week after cortisone injections, the well-known thymic atrophy was observed. Five weeks after 12 hydrocortisone injections, the cortical volume fraction (Vc), cortical/medullary ratio (C/M), the number of thymocytes and CD4/CD8 profiles were in the range that characterizes younger mice, compared with PBS-injected mice, uninjected controls, or mice given a single hydrocortisone injection 5 weeks earlier. It seems as if thymic involution with age was suspended during the period of glucocorticoid exposure.
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Received: 26 February 1997 / Accepted: 9 April 1997
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Bar-Dayan, Y., Aronson, M. & Small, M. Thymic aging in ICR female mice is suspended by prolonged hydrocortisone exposure. Cell Tissue Res 290, 609–613 (1997). https://doi.org/10.1007/s004410050966
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DOI: https://doi.org/10.1007/s004410050966