Abstract.
Axonal growth cones navigate long distances along specific pathways to establish complex patterns of neuronal connections. A growing number of signals have been identified that participate in these steering decisions. This review will concentrate on a large and growing family of chemorepellents, the semaphorins. This family contains both secreted and membrane-bound proteins expressed in many neuronal and non-neuronal tissues of invertebrates and vertebrates. Ongoing studies have given us a better understanding of how their highly conserved signalling system is involved in patterning neuronal connections.
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Received: 29 April 1997 / Accepted: 3 June 1997
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Mark, M., Lohrum, M. & Püschel, A. Patterning neuronal connections by chemorepulsion: the semaphorins. Cell Tissue Res 290, 299–306 (1997). https://doi.org/10.1007/s004410050934
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DOI: https://doi.org/10.1007/s004410050934