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Toll-like receptor bioactivity in endothelial progenitor cells

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Abstract

Cardiovascular disease is the main cause of death globally that can be mitigated by the modulation of angiogenesis. To achieve this goal, the application of endothelial progenitor cells and other stem cell types is useful. Following the onset of cardiovascular disease and pro-inflammatory conditions as seen during bacterial sepsis, endothelial progenitor cells enter systemic circulation in response to multiple cytokines and activation of various intracellular mechanisms. The critical role of Toll-like receptors has been previously identified in the dynamics of various cell types, in particular, immune cells. To our knowledge, there are a few experiments related to the role of Toll-like receptors in endothelial progenitor cell activity. Emerging data point of endothelial progenitor cells and other stem cells having the potential to express Toll-like receptors to control different activities such as multipotentiality and dynamics of growth. In this review article, we aim to collect data related to the role of Toll-like receptors in endothelial progenitor cells bioactivity and angiogenic potential.

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Acknowledgments

We would like to thank the personnel of Stem Cell Research Center.

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  1. Fatemeh Roodbari and Reza Rahbarghazi contributed equally to this work.

Authors and Affiliations

  1. Department of Microbiology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran

    Morteza Heidarzadeh & Fatemeh Roodbari

  2. Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Morteza Heidarzadeh, Shirin Saberianpour & Reza Rahbarghazi

  3. Department of Clinical Biochemistry and Laboratory Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Mehdi Hassanpour

  4. Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Mahdi Ahmadi

  5. Department of Applied Cell Sciences, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

    Reza Rahbarghazi

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  1. Morteza Heidarzadeh
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Correspondence to Fatemeh Roodbari or Reza Rahbarghazi.

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This work was financially supported by a grant (IR.TBZMED.REC.1397.998) from Tabriz University of Medical Sciences.

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Heidarzadeh, M., Roodbari, F., Hassanpour, M. et al. Toll-like receptor bioactivity in endothelial progenitor cells. Cell Tissue Res 379, 223–230 (2020). https://doi.org/10.1007/s00441-019-03119-2

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