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Protective role of exogenous recombinant peroxiredoxin 6 under ischemia-reperfusion injury of kidney

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Abstract

Peroxiredoxin 6 (Prx6) is an important antioxidant enzyme with various functions in the cell. Prx6 reduces a wide range of peroxide substrates, playing a leading role in maintaining the redox homeostasis of mammalian cells. In addition to the peroxidase activity, a phospholipase A2-like activity was demonstrated for Prx6, which plays an important role in the metabolism of membrane phospholipids. Besides that, due to its peroxidase and phospholipase activities, Prx6 participates in intracellular and intercellular signal transduction, thus triggering regenerative processes in the cell, suppressing apoptosis caused by various factors, including ischemia-reperfusion injuries. A nephroprotective effect of exogenous recombinant Prx6 administered before ischemia-reperfusion injury was demonstrated on an animal model. Exogenous Prx6 effectively alleviates the severeness of renal ischemia-reperfusion injuries and facilitates normalization of their structural and functional conditions. Infusion of exogenous Prx6 increases the survival rate of experimental animals by almost 3 times. Application of exogenous Prx6 can be an effective approach in the prevention and treatment of renal ischemia-reperfusion kidney lesions and in preserving isolated kidneys during transplantation.

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Funding

This work was supported by the Russian Foundation for Basic Research (grant nos. 17-04-00356-a and 19-04-00080-a) and the “Molecular and Cell Biology” program of the Presidium of the Russian Academy of Sciences.

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Correspondence to M. G. Sharapov.

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The authors declare that they have no conflict of interest.

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The study protocol was approved by the institutional Ethics Committee of Institute of Cell Biophysics RAS and all experiments were carried out according to international regulations listed in the European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes (ETS 123) and ICB RAS Manual for Working with Laboratory Animal no. 57 (30.12.2011).

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Goncharov, R.G., Rogov, K.A., Temnov, A.A. et al. Protective role of exogenous recombinant peroxiredoxin 6 under ischemia-reperfusion injury of kidney. Cell Tissue Res 378, 319–332 (2019). https://doi.org/10.1007/s00441-019-03073-z

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  • DOI: https://doi.org/10.1007/s00441-019-03073-z

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