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Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes

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Abstract

In recent years, human umbilical cord blood has emerged as a rich source of stem, stromal and immune cells for cell-based therapy. Among the stem cells from umbilical cord blood, CD45+ multipotent stem cells and CD90+ mesenchymal stem cells have the potential to treat type I diabetes mellitus (T1DM), to correct autoimmune dysfunction and replenish β-cell numbers and function. In this review, we compare the general characteristics of umbilical cord blood-derived multipotent stem cells (UCB-SCs) and umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) and introduce their applications in T1DM. Although there are some differences in surface marker expression between UCB-SCs and UCB-MSCs, the two cell types display similar functions such as suppressing function of stimulated lymphocytes and imparting differentiation potential to insulin-producing cells (IPCs) in the setting of low immunogenicity, thereby providing a promising and safe approach for T1DM therapy.

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Funding

This research was supported by the Juvenile Diabetes Research Foundation (Grant No. 17-2013-288), NIH (Grant No. 1DP2CA195763-01) and Juvenile Diabetes Research Foundation (Grant No. 17-2013-491).

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  1. Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, 845 Health Sciences Road, Irvine, CA, 92697, USA

    Rachel Stiner, Michael Alexander, Guangyang Liu, Yongjun Liu, Jingxia Yu, Egest J. Pone, Weian Zhao & Jonathan R. T. Lakey

  2. Department of Surgery, University of California, Irvine, 333 City Boulevard West, Suite 1600, Orange, CA, 92868, USA

    Rachel Stiner, Michael Alexander, Guangyang Liu, Jingxia Yu & Jonathan R. T. Lakey

  3. Department of Biomedical Engineering, University of California, Irvine, 402 E Peltason Dr, Irvine, CA, 92697, USA

    Michael Alexander, Guangyang Liu, Yongjun Liu, Jingxia Yu, Egest J. Pone, Weian Zhao & Jonathan R. T. Lakey

  4. Baylx, Inc., 23 Spectrum Pointe Dr Suite 207, Lake Forest, CA, 92630, USA

    Guangyang Liu, Wenbin Liao, Yongjun Liu, Jingxia Yu, Weian Zhao & Jonathan R. T. Lakey

  5. Department of Pharmaceutical Sciences, University of California, Irvine, 147 Bison Modular, Irvine, CA, 92697, USA

    Yongjun Liu, Egest J. Pone & Weian Zhao

  6. Chao Family Comprehensive Cancer Center, University of California, Irvine, 101 The City Dr S, Orange, CA, 92868, USA

    Egest J. Pone & Weian Zhao

  7. Department of Biological Chemistry, University of California, Irvine, Irvine, CA, 92697, USA

    Egest J. Pone & Weian Zhao

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  1. Rachel Stiner
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  2. Michael Alexander
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  3. Guangyang Liu
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  7. Egest J. Pone
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  8. Weian Zhao
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  9. Jonathan R. T. Lakey
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Correspondence to Jonathan R. T. Lakey.

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Stiner, R., Alexander, M., Liu, G. et al. Transplantation of stem cells from umbilical cord blood as therapy for type I diabetes. Cell Tissue Res 378, 155–162 (2019). https://doi.org/10.1007/s00441-019-03046-2

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  • DOI: https://doi.org/10.1007/s00441-019-03046-2

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