Myths, reality and future of mesenchymal stem cell therapy

Abstract

Mesenchymal stem cell (MSC) therapy represents an alternative approach for tissue regeneration and inflammation control. In spite of a huge amount of preclinical data that has been accumulated on the therapeutic properties of MSCs, there are many conflicting results, possibly due to differences in the properties of MSCs obtained from different sources or underestimated mechanisms of MSC in vivo behavior. This review consolidates the in vivo effects of MSC therapy, discusses the fate of MSCs after intravascular and local delivery and proposes possible trends in MSC therapy.

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Funding

This work was supported by the Russian Science Foundation grant no. 14-25-00179.

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Correspondence to E. V. Svirshchevskaya.

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All procedures involving animals were in accordance with the ethical standards of the institution.

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Poltavtseva, R.A., Poltavtsev, A.V., Lutsenko, G.V. et al. Myths, reality and future of mesenchymal stem cell therapy. Cell Tissue Res 375, 563–574 (2019). https://doi.org/10.1007/s00441-018-2961-4

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Keywords

  • Mesenchymal stem cells
  • Cell therapy
  • Exosomes
  • Liposomes
  • Diabetes mellitus