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MicroRNAs in the hypothalamic control of energy homeostasis

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  • Atasoy D, Betley JN, Su HH, Sternson SM (2012) Deconstruction of a neural circuit for hunger. Nature 488:172–177

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Caquineau C, Leng G, Guan XM, Jiang M, Van der Ploeg L, Douglas AJ (2006) Effects of alpha-melanocyte-stimulating hormone on magnocellular oxytocin neurons and their activation at intromission in male rats. J Neuroendocrinol 18:685–691

    Article  CAS  PubMed  Google Scholar 

  • Chmielarz P, Konovalova J, Najam SS, Alter H, Piepponen TP, Erfle H, Sonntag KC, Schütz G, Vinnikov IA, Domanskyi A (2017) Dicer and microRNAs protect adult dopamine neurons. Cell Death Dis 8:e2813

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Crepin D, Benomar Y, Riffault L, Amine H, Gertler A, Taouis M (2014) The over-expression of miR-200a in the hypothalamus of ob/ob mice is linked to leptin and insulin signaling impairment. Mol Cell Endocrinol 384:1–11

    Article  CAS  PubMed  Google Scholar 

  • Derghal A, Djelloul M, Airault C, Pierre C, Dallaporta M, Troadec JD, Tillement V, Tardivel C, Bariohay B, Trouslard J, Mounien L (2015) Leptin is required for hypothalamic regulation of miRNAs targeting POMC 3′UTR. Front Cell Neurosci 9:172

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Domanskyi A, Vinnikov IA (2017) Can we treat neurodegenerative diseases by preventing an age-related decline in microRNA expression? Neural Regen Res 12:1602

    Article  PubMed  PubMed Central  Google Scholar 

  • Fenselau H, Campbell JN, Verstegen AM, Madara JC, Xu J, Shah BP, Resch JM, Yang Z, Mandelblat-Cerf Y, Livneh Y, Lowell BB (2017) A rapidly acting glutamatergic ARC-->PVH satiety circuit postsynaptically regulated by alpha-MSH. Nat Neurosci 20:42–51

    Article  CAS  PubMed  Google Scholar 

  • Fiorenza A, Lopez-Atalaya JP, Rovira V, Scandaglia M, Geijo-Barrientos E, Barco A (2016) Blocking miRNA biogenesis in adult forebrain neurons enhances seizure susceptibility, fear memory, and food intake by increasing neuronal responsiveness. Cereb Cortex 26:1619–1633

    Article  PubMed  Google Scholar 

  • Garfield AS, Li C, Madara JC, Shah BP, Webber E, Steger JS, Campbell JN, Gavrilova O, Lee CE, Olson DP et al (2015) A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci 18:863–871

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Greenman Y, Kuperman Y, Drori Y, Asa SL, Navon I, Forkosh O, Gil S, Stern N, Chen A (2013) Postnatal ablation of POMC neurons induces an obese phenotype characterized by decreased food intake and enhanced anxiety-like behavior. Mol Endocrinol 27:1091–1102

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hume C, Sabatier N, Menzies J (2017) High-sugar, but not high-fat, food activates supraoptic nucleus neurons in the male rat. Endocrinology 158:2200–2211

    Article  PubMed  Google Scholar 

  • Konopka W, Kiryk A, Novak M, Herwerth M, Parkitna JR, Wawrzyniak M, Kowarsch A, Michaluk P, Dzwonek J, Arnsperger T et al (2010) MicroRNA loss enhances learning and memory in mice. J Neurosci 30:14835–14842

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kublaoui BM, Gemelli T, Tolson KP, Wang Y, Zinn AR (2008) Oxytocin deficiency mediates hyperphagic obesity of Sim1 haploinsufficient mice. Mol Endocrinol 22:1723–1734

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Maejima Y, Sakuma K, Santoso P, Gantulga D, Katsurada K, Ueta Y, Hiraoka Y, Nishimori K, Tanaka S, Shimomura K, Yada T (2014) Oxytocinergic circuit from paraventricular and supraoptic nuclei to arcuate POMC neurons in hypothalamus. FEBS Lett 588:4404–4412

    Article  CAS  PubMed  Google Scholar 

  • Mang GM, Pradervand S, Du NH, Arpat AB, Preitner F, Wigger L, Gatfield D, Franken P (2015) A neuron-specific deletion of the microRNA-processing enzyme DICER induces severe but transient obesity in mice. PLoS One 10:e0116760

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mori MA, Thomou T, Boucher J, Lee KY, Lallukka S, Kim JK, Torriani M, Yki-Jarvinen H, Grinspoon SK, Cypess AM, Kahn CR (2014) Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy. J Clin Invest 124:3339–3351

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Motojima Y, Kawasaki M, Matsuura T, Saito R, Yoshimura M, Hashimoto H, Ueno H, Maruyama T, Suzuki H, Ohnishi H et al (2016) Effects of peripherally administered cholecystokinin-8 and secretin on feeding/drinking and oxytocin-mRFP1 fluorescence in transgenic rats. Neurosci Res 109:63–69

    Article  CAS  PubMed  Google Scholar 

  • Ong ZY, Bongiorno DM, Hernando MA, Grill HJ (2017) Effects of endogenous oxytocin receptor signaling in nucleus tractus solitarius on satiation-mediated feeding and thermogenic control in male rats. Endocrinology 158:2826–2836

    Article  PubMed  PubMed Central  Google Scholar 

  • Pico C, Jilkova ZM, Kus V, Palou A, Kopecky J (2011) Perinatal programming of body weight control by leptin: putative roles of AMP kinase and muscle thermogenesis. Am J Clin Nutr 94:1830S–1837S

    Article  CAS  Google Scholar 

  • Schneeberger M, Altirriba J, Garcia A, Esteban Y, Castano C, Garcia-Lavandeira M, Alvarez CV, Gomis R, Claret M (2012) Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesity. Mol Metab 2:74–85

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shah BP, Vong L, Olson DP, Koda S, Krashes MJ, Ye C, Yang Z, Fuller PM, Elmquist JK, Lowell BB (2014) MC4R-expressing glutamatergic neurons in the paraventricular hypothalamus regulate feeding and are synaptically connected to the parabrachial nucleus. Proc Natl Acad Sci U S A 111:13193–13198

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Vinnikov IA, Hajdukiewicz K, Reymann J, Beneke J, Czajkowski R, Roth LC, Novak M, Roller A, Dorner N, Starkuviene V et al (2014) Hypothalamic miR-103 protects from hyperphagic obesity in mice. J Neurosci 34:10659–10674

    Article  CAS  PubMed  Google Scholar 

  • Vinnikov IA, Domanskyi A, Konopka W (2016) Continuous delivery of oligonucleotides into the brain. In physiology. Humana Press, Totowa, pp 1–29

    Google Scholar 

  • Wu Z, Xu Y, Zhu Y, Sutton AK, Zhao R, Lowell BB, Olson DP, Tong Q (2012) An obligate role of oxytocin neurons in diet induced energy expenditure. PLoS One 7:e45167

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Yang SB, Tien AC, Boddupalli G, Xu AW, Jan YN, Jan LY (2012) Rapamycin ameliorates age-dependent obesity associated with increased mTOR signaling in hypothalamic POMC neurons. Neuron 75:425–436

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang G, Cai D (2011) Circadian intervention of obesity development via resting-stage feeding manipulation or oxytocin treatment. Am J Physiol Endocrinol Metab 301:E1004–E1012

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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This work was funded by the National Natural Science Foundation of China (31771433) and Shanghai Jiao Tong University (AF0800056) to I.A.V., and National Centre for Research and Development, Poland, 3/POLTUR-1/2016/APPETITE-MIR to W.K.

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Correspondence to Ilya A. Vinnikov.

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Najam, S.S., Zglinicki, B., Vinnikov, I.A. et al. MicroRNAs in the hypothalamic control of energy homeostasis. Cell Tissue Res 375, 173–177 (2019).

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