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Neutrophil–lymphatic interactions during acute and chronic disease

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The lymphatic system aids in osmoregulation through tissue fluid transport, but is also designed to support communication between cells of the innate and adaptive immune systems. During inflammation, changes within the lymphatics can result in an altered response to infection. Neutrophils have been described as one key cell type that facilitates antigen capture and presentation within the lymphatic system, enabling an effective adaptive immune response. Disruption of neutrophil recruitment during inflammation, due to alterations in lymphatics, is a growing area of study due to their key role in infection resolution. In this review, we discuss the currently known methods by which neutrophils are recruited to the lymphatic system and what subsequent effects they have on resident and recruited cells within the lymph vessels and nodes. We also discuss the changes in neutrophil activation and recruitment during chronic inflammatory diseases and their relationship to lymphatic dysfunction.

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This work is supported by the University of Calgary start-up fund to SL, provided by the Dianne & Irving Kipnes Foundation, and the Canadian Institute of Health Research (CIHR) Bridge Fund to SL.

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Correspondence to Shan Liao.

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Stephens, M., Liao, S. Neutrophil–lymphatic interactions during acute and chronic disease. Cell Tissue Res 371, 599–606 (2018).

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