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Epigenetic regulation of neuroblastoma development

A Correction to this article was published on 02 February 2018

This article has been updated

Abstract

In recent years, technological advances have enabled a detailed landscaping of the epigenome and the mechanisms of epigenetic regulation that drive normal cell function, development and cancer. Rather than merely a structural entity to support genome compaction, we now look at chromatin as a very dynamic and essential constellation that is actively participating in the tight orchestration of transcriptional regulation as well as DNA replication and repair. The unique feature of chromatin flexibility enabling fast switches towards more or less restricted epigenetic cellular states is, not surprisingly, intimately connected to cancer development and treatment resistance, and the central role of epigenetic alterations in cancer is illustrated by the finding that up to 50% of all mutations across cancer entities affect proteins controlling the chromatin status. We summarize recent insights into epigenetic rewiring underlying neuroblastoma (NB) tumor formation ranging from changes in DNA methylation patterns and mutations in epigenetic regulators to global effects on transcriptional regulatory circuits that involve key players in NB oncogenesis. Insights into the disruption of the homeostatic epigenetic balance contributing to developmental arrest of sympathetic progenitor cells and subsequent NB oncogenesis are rapidly growing and will be exploited towards the development of novel therapeutic strategies to increase current survival rates of patients with high-risk NB.

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  • 02 February 2018

    The authorship names of this paper are incorrect.

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Correspondence to Kaat Durinck.

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The original version of this article was revised: The authorship names of this paper are incorrect. The name of the first author is Durinck K and the second author name is Speleman F. The correct presentation is given above.

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Durinck, K., Speleman, F. Epigenetic regulation of neuroblastoma development. Cell Tissue Res 372, 309–324 (2018). https://doi.org/10.1007/s00441-017-2773-y

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Keywords

  • Histone code
  • Chromatin remodeling
  • Core regulatory circuits
  • Non-coding RNA
  • Epigenetic therapy