Tissue-derived scaffolds and cells for articular cartilage tissue engineering: characteristics, applications and progress
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There are many factors to consider in the field of tissue engineering. For articular cartilage repair, this includes seed cells, scaffolds and chondrotrophic hormones. This review primarily focuses on the seed cells and scaffolds. Extracellular matrix proteins provide a natural scaffold for cell attachment, proliferation and differentiation. The structure and composition of tissue-derived scaffolds and native tissue are almost identical. As such, tissue-derived scaffolds hold great promise for biomedical applications. However, autologous tissue-derived scaffolds also have many drawbacks for transplantation, as harvesting autografts is limited to available donor sites and requires secondary surgery, therefore imparting additional damage to the body. This review summarizes and analyzes various cell sources and tissue-derived scaffolds applied in orthopedic tissue engineering.
KeywordsTissue engineering Tissue-derived scaffold Seed cells Extracellular matrix Articular cartilage
This study was supported by the National Natural Science Foundation of China (81572148), National Key Research and Development Program of China (2016YFC1102104), the People’s Liberation Army 13th 5-year plan period (BWS13C029), Beijing Municipal Science and Technology Project (Z161100005016059) and Basic research project of Education Department of Heilongjiang (2016-KYYWF-0548).
Compliance with ethical standards
No competing financial interests exist.
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