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Neutrophils in viral infection

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Abstract

Neutrophils are the first wave of recruited immune cells to sites of injury or infection and are crucial players in controlling bacterial and fungal infections. Although the role of neutrophils during bacterial or fungal infections is well understood, their impact on antiviral immunity is much less studied. Furthermore, neutrophil function in tumor pathogenesis and cancer treatment has recently received much attention, particularly within the context of oncolytic virus infection where neutrophils produce antitumor cytokines and enhance oncolysis. In this review, multiple functions of neutrophils in viral infections and immunity are discussed. Understanding the role of neutrophils during viral infection may provide insight into the pathogenesis of virus infections and the outcome of virus-based therapies.

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Abbreviations

CMV:

Cytomegalovirus

DC:

Dendritic cell

EBV:

Epstein–Barr virus

EHEC:

Enterohemorrhagic Escherichia. coli

G-CSF:

Granulocyte colony-stimulating factor

HCMV:

Human cytomegalovirus

HIV:

Human immunodeficiency virus

HSV:

Herpes simplex virus

IAV:

Influenza A virus

IFN:

Interferon

IL:

Interleukin

IVM:

Intravital microscopy

LCMV:

Lymphocytic choriomeningitis virus

MPO:

Myeloperoxidase

NET:

Neutrophil extracellular trap

OPN:

Osteopontin

OVT:

Oncolytic virus therapy

PRR:

Pattern recognition receptor

ROS:

Reactive oxygen species

RSV:

Respiratory syncytial virus

TLR:

Toll-like receptor

TNF:

Tumor necrosis factor

TREM-1:

Triggering receptors expressed on myeloid cells-1

VSV:

Vesicular stomatitis virus

WNV:

West Nile virus

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Author notes

  1. Victor Naumenko and Madison Turk contributed equally to this work and are co-first authors.

Authors and Affiliations

  1. Department of Microbiology, Immunology and Infectious Diseases, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, University of Calgary, HRIC 3330 Hospital Drive N.W, Calgary, Alberta, T2N 4N1, Canada

    Victor Naumenko, Madison Turk, Craig N. Jenne & Seok-Joo Kim

  2. National University of Science and Technology “MISIS”, Leninskiy prospect 4, 119991, Moscow, Russia

    Victor Naumenko

  3. Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, HRIC 2C26, 3280 Hospital Drive N.W., Calgary, Alberta, T2N 4N1, Canada

    Craig N. Jenne

  4. Calvin, Phoebe & Joan Snyder Institute for Chronic Diseases, Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, HRIC 4C49, 3280 Hospital Drive N.W., Calgary, Alberta, T2N 4N1, Canada

    Seok-Joo Kim

Authors
  1. Victor Naumenko
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  2. Madison Turk
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  3. Craig N. Jenne
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  4. Seok-Joo Kim
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Corresponding authors

Correspondence to Craig N. Jenne or Seok-Joo Kim.

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Naumenko, V., Turk, M., Jenne, C.N. et al. Neutrophils in viral infection. Cell Tissue Res 371, 505–516 (2018). https://doi.org/10.1007/s00441-017-2763-0

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  • DOI: https://doi.org/10.1007/s00441-017-2763-0

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