Abstract
Adult hippocampal neurogenesis is the process by which new functional neurons are added to the adult dentate gyrus of the hippocampus. Animal studies have shown that the degree of adult hippocampal neurogenesis is regulated by local environmental cues as well as neural network activities. Furthermore, accumulating evidence has suggested that adult hippocampal neurogenesis plays prominent roles in hippocampus-dependent brain functions. In this review, we summarize the mechanisms underlying the regulation of adult hippocampal neurogenesis at various developmental stages and propose how adult-born neurons contribute to structural and functional hippocampal plasticity.
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Acknowledgments
We thank M.L. Gage and S. Marshall for comments on the manuscript. This work was supported by NIH R01 MH095741, NIH U01 MH106882, The G. Harold and Leila Y. Mathers Charitable Foundation, The Leona M. and Harry B. Helmsley Charitable Trust (grant #2012-PG-MED00), Annette C. Merle-Smith, JPB Foundation and The McKnight Foundation, The Kanae foundation for the Promotion of Medical Science. T.T. was supported by Japan Society for the Promotion of Science. We thank Mary Lynn Gage for editorial comments and Veronika Mertens for illustrations.
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Toda, T., Gage, F.H. Review: adult neurogenesis contributes to hippocampal plasticity. Cell Tissue Res 373, 693–709 (2018). https://doi.org/10.1007/s00441-017-2735-4
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DOI: https://doi.org/10.1007/s00441-017-2735-4