Skip to main content

Advertisement

Log in

A tale of two orgins: do myofibroblasts originate from different sources in wound healing and fibrosis?

  • At-a-glance article
  • Published:
Cell and Tissue Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  • Bissell DM (1998) Hepatic fibrosis as wound repair: a progress report. J Gastroenterol 33(2):295–302

    Article  CAS  PubMed  Google Scholar 

  • Bissell DM (2010) Inflammation and hepatic fibrosis. Semin Liver Dis 30(3):211–214

    Article  PubMed  Google Scholar 

  • Fligny C, Duffield JS (2013) Activation of pericytes: recent insights into kidney fibrosis and microvascular rarefaction. Curr Opin Rheumatol 25(1):78–86

    Article  PubMed  Google Scholar 

  • Friedman SL, Roll FJ, Boyles J, Bissell DM (1985) Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci U S A 82(24):8681–8685

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hinz B (2010) The myofibroblast: paradigm for a mechanically active cells. J Biomech 43:146–155

  • Hinz B (2016) Myofibroblasts. Exp Eye Res 142:56–70

    Article  CAS  PubMed  Google Scholar 

  • Koivisto L, Heino J, Hakkinen L, Larjava H (2014) Integrins in wound healing. Adv Wound Care (New Rochelle) 3(12):762–783

    Article  PubMed Central  Google Scholar 

  • Lin RJ, Su ZZ, Liang SM, Chen YY, Shu XR, Nie RQ, Wang JF, Xie SL (2016) Role of circulating fibrocytes in cardiac fibrosis. Chin Med J (Engl) 129(3):326–331

    Article  Google Scholar 

  • Liu S, Xu SW, Blumbach K, Eastwood M, Denton CP, Eckes B, Krieg T, Abraham DJ, Leask A (2010) Expression of integrin beta1 by fibroblasts is required for tissue repair in vivo. J Cell Sci 123(Pt 21):3674–3682

    Article  CAS  PubMed  Google Scholar 

  • Liu S, Herault Y, Pavlovic G, Leask A (2014) Skin progenitor cells contribute to bleomycin-induced skin fibrosis. Arthritis Rheum 66(3):707–713

    Article  CAS  Google Scholar 

  • Marangoni RG, Korman BD, Wei J, Wood TA, Graham LV, Whitfield ML, Scherer PE, Tourtellotte WG, Varga J (2015) Myofibroblasts in murine cutaneous fibrosis originate from adiponectin-positive intradermal progenitors. Arthritis Rheum 67(4):1062–1073

    Article  CAS  Google Scholar 

  • Nakagawa N, Duffield JS (2013) Myofibroblasts in fibrotic kidneys. Curr Pathobiol Rep 1(3)

  • Rajkumar VS, Sundberg C, Abraham DJ, Rubin K, Black CM (1999) Activation of microvascular pericytes in autoimmune Raynaud’s phenomenon and systemic sclerosis. Arthritis Rheum 42(5):930–41

    Article  CAS  Google Scholar 

  • Rajkumar VS, Howell K, Csiszar K, Denton CP, Black CM, Abraham DJ (2005) Shared expression of phenotypic markers in systemic sclerosis indicates a convergence of pericytes and fibroblasts to a myofibroblast lineage in fibrosis. Arthritis Res Ther 7(5):R1113–1123

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ramirez H, Patel SB, Pastar I (2014) The role of TGFbeta signaling in wound epithelialization. Adv Wound Care (New Rochelle) 3(7):482–491

    Article  Google Scholar 

  • Ren S, Duffield JS (2013) Pericytes in kidney fibrosis. Curr Opin Nephrol Hypertens 22(4):471–480

    Article  CAS  PubMed  Google Scholar 

  • Seo E, Basu-Roy U, Gunaratne PH, Coarfa C, Lim DS, Basilico C, Mansukhani A (2013) SOX2 regulates YAP1 to maintain stemness and determine cell fate in the osteo-adipo lineage. Cell Rep 3(6):2075–87

    Article  CAS  PubMed  Google Scholar 

  • Sowa Y, Imura T, Numajiri T, Takeda K, Mabuchi Y, Matsuzaki Y, Nishino K (2013) Adipose stromal cells contain phenotypically distinct adipogenic progenitors derived from neural crest. PLoS ONE 8(12):e84206

    Article  PubMed  PubMed Central  Google Scholar 

  • Tsang M, Leask A (2015) CCN2 is required for recruitment of Sox2-expressing cells during cutaneous tissue repair. J Cell Commun Signal 9(4):341–346

    Article  PubMed  Google Scholar 

  • Wei J, Bhattacharyya S, Tourtellotte WG, Varga J (2011) Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy. Autoimmun Rev 10(5):267–275

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Andrew Leask.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hutchenreuther, J., Leask, A. A tale of two orgins: do myofibroblasts originate from different sources in wound healing and fibrosis?. Cell Tissue Res 365, 507–509 (2016). https://doi.org/10.1007/s00441-016-2419-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00441-016-2419-5

Keywords

Navigation