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The role of catecholamines in mesenchymal stem cell fate

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Abstract

Mesenchymal stem cells (MSCs) are multipotent stem cells found in many adult tissues, especially bone marrow (BM) and are capable of differentiation into various lineage cells such as osteoblasts, adipocytes, chondrocytes and myocytes. Moreover, MSCs can be mobilized from connective tissue into circulation and from there to damaged sites to contribute to regeneration processes. MSCs commitment and differentiation are controlled by complex activities involving signal transduction through cytokines and catecholamines. There has been an increasing interest in recent years in the neural system, functioning in the support of stem cells like MSCs. Recent efforts have indicated that the catecholamine released from neural and not neural cells could be affected characteristics of MSCs. However, there have not been review studies of most aspects involved in catecholamines-mediated functions of MSCs. Thus, in this review paper, we will try to describe the current state of catecholamines in MSCs destination and discuss strategies being used for catecholamines for migration of these cells to damaged tissues. Then, the role of the nervous system in the induction of osteogenesis, adipogenesis, chondrogenesis and myogenesis from MSCs is discussed. Recent progress in studies of signaling transduction of catecholamines in determination of the final fate of MSCs is highlighted. Hence, the knowledge of interaction between MSCs with the neural system could be applied towards the development of new diagnostic and treatment alternatives for human diseases.

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Abbreviations

ATF4:

Activating transcription factor 4

BARK:

β-Adr kinase

BM:

Bone marrow

BMSCs:

Bone marrow stem cells

BMP4:

Bone morphogenetic proteins

C/EBP:

CCAAT/enhancer-binding protein

DBH:

Dopamine-b-Hydroxylase

DEHP:

Bis (2-Ethylhexyl) phthalate

Ebf1:

Early B-cell factor 1

EPAC:

Exchange protein activated by adenylyl cyclase

EPO:

Erythropoietin

FGF:

Fibroblast growth factor

GPC:

Growth plate chondrocytes

GPCRs:

G-protein-coupled receptors

GCs:

Glucocorticoids

HGF:

Hepatocyte growth factor

HSCs:

Hematopoietic stem cells

IGF-1:

Insulin-like growth factor-1

IRFs:

Interferon regulatory factors

MAFbx:

Muscle atrophy F-box protein

MKP-1:

Mitogen-activated protein kinase phosphatase

MSCs:

Mesenchymal stem cells

MuRF1:

Muscle ring finger1

OGP:

Osteogenic growth peptide

PB:

Peripheral blood

PDEs:

Phosphodiesterase proteins

PGE2:

Prostaglandin E2

pRb:

Retinoblastoma cell cycle-related proteins

PKA:

Protein kinase A

ROS:

Reactive oxygen species

SDF-1:

Stromal-derived factor-1

SHH:

Sonic Hedgehog protein

SNS:

Sympathetic nervous system

SREBPs:

Sterol regulatory element binding proteins

S1P:

Sphingosine1-phosphate

TBT:

Tributyltin

TB4:

Thymosin β

TF:

Transcription factors

TH:

Tyrosine hydroxylase

TGF-β:

Transforming growth factor-β

TLR-9:

Toll-like receptor 9

4EBP1:

eIF4E binding protein1

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Acknowledgments

We would like to acknowledge Thomas J. Kelly for his revisions and thank all our colleagues at the Department of Hematology in Tarbiat Modares University for assistance with the manuscript. This study was supported by Tarbiat Modares University.

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Authors and Affiliations

  1. Bone Marrow Transplantation Center, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Abbas Hajifathali

  2. Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

    Fakhredin Saba, Amir Atashi & Masoud Soleimani

  3. Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands

    Esmaeil Mortaz

  4. Department of Molecular Genetics, National Institute for Genetic Engineering and Biotechnology, Tehran, Iran

    Mahsa Rasekhi

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  1. Abbas Hajifathali
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  2. Fakhredin Saba
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  3. Amir Atashi
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  4. Masoud Soleimani
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  5. Esmaeil Mortaz
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Correspondence to Amir Atashi or Masoud Soleimani.

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Abbas Hajifathali and Fakhredin Saba contributed equally to this work.

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Hajifathali, A., Saba, F., Atashi, A. et al. The role of catecholamines in mesenchymal stem cell fate. Cell Tissue Res 358, 651–665 (2014). https://doi.org/10.1007/s00441-014-1984-8

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