Cell and Tissue Research

, Volume 358, Issue 3, pp 651–665 | Cite as

The role of catecholamines in mesenchymal stem cell fate

  • Abbas Hajifathali
  • Fakhredin Saba
  • Amir Atashi
  • Masoud Soleimani
  • Esmaeil Mortaz
  • Mahsa Rasekhi


Mesenchymal stem cells (MSCs) are multipotent stem cells found in many adult tissues, especially bone marrow (BM) and are capable of differentiation into various lineage cells such as osteoblasts, adipocytes, chondrocytes and myocytes. Moreover, MSCs can be mobilized from connective tissue into circulation and from there to damaged sites to contribute to regeneration processes. MSCs commitment and differentiation are controlled by complex activities involving signal transduction through cytokines and catecholamines. There has been an increasing interest in recent years in the neural system, functioning in the support of stem cells like MSCs. Recent efforts have indicated that the catecholamine released from neural and not neural cells could be affected characteristics of MSCs. However, there have not been review studies of most aspects involved in catecholamines-mediated functions of MSCs. Thus, in this review paper, we will try to describe the current state of catecholamines in MSCs destination and discuss strategies being used for catecholamines for migration of these cells to damaged tissues. Then, the role of the nervous system in the induction of osteogenesis, adipogenesis, chondrogenesis and myogenesis from MSCs is discussed. Recent progress in studies of signaling transduction of catecholamines in determination of the final fate of MSCs is highlighted. Hence, the knowledge of interaction between MSCs with the neural system could be applied towards the development of new diagnostic and treatment alternatives for human diseases.


Mesenchymal stem cell Differentiation Catecholamines Adrenergic signaling Migration 



Activating transcription factor 4


β-Adr kinase


Bone marrow


Bone marrow stem cells


Bone morphogenetic proteins


CCAAT/enhancer-binding protein




Bis (2-Ethylhexyl) phthalate


Early B-cell factor 1


Exchange protein activated by adenylyl cyclase




Fibroblast growth factor


Growth plate chondrocytes


G-protein-coupled receptors




Hepatocyte growth factor


Hematopoietic stem cells


Insulin-like growth factor-1


Interferon regulatory factors


Muscle atrophy F-box protein


Mitogen-activated protein kinase phosphatase


Mesenchymal stem cells


Muscle ring finger1


Osteogenic growth peptide


Peripheral blood


Phosphodiesterase proteins


Prostaglandin E2


Retinoblastoma cell cycle-related proteins


Protein kinase A


Reactive oxygen species


Stromal-derived factor-1


Sonic Hedgehog protein


Sympathetic nervous system


Sterol regulatory element binding proteins






Thymosin β


Transcription factors


Tyrosine hydroxylase


Transforming growth factor-β


Toll-like receptor 9


eIF4E binding protein1



We would like to acknowledge Thomas J. Kelly for his revisions and thank all our colleagues at the Department of Hematology in Tarbiat Modares University for assistance with the manuscript. This study was supported by Tarbiat Modares University.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Abbas Hajifathali
    • 1
  • Fakhredin Saba
    • 2
  • Amir Atashi
    • 2
  • Masoud Soleimani
    • 2
  • Esmaeil Mortaz
    • 3
  • Mahsa Rasekhi
    • 4
  1. 1.Bone Marrow Transplantation Center, Taleghani HospitalShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of Hematology, Faculty of Medical SciencesTarbiat Modares UniversityTehranIran
  3. 3.Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of ScienceUtrecht UniversityUtrechtThe Netherlands
  4. 4.Department of Molecular GeneticsNational Institute for Genetic Engineering and BiotechnologyTehranIran

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