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Cell and Tissue Research

, Volume 358, Issue 3, pp 651–665 | Cite as

The role of catecholamines in mesenchymal stem cell fate

  • Abbas Hajifathali
  • Fakhredin Saba
  • Amir Atashi
  • Masoud Soleimani
  • Esmaeil Mortaz
  • Mahsa Rasekhi
Review

Abstract

Mesenchymal stem cells (MSCs) are multipotent stem cells found in many adult tissues, especially bone marrow (BM) and are capable of differentiation into various lineage cells such as osteoblasts, adipocytes, chondrocytes and myocytes. Moreover, MSCs can be mobilized from connective tissue into circulation and from there to damaged sites to contribute to regeneration processes. MSCs commitment and differentiation are controlled by complex activities involving signal transduction through cytokines and catecholamines. There has been an increasing interest in recent years in the neural system, functioning in the support of stem cells like MSCs. Recent efforts have indicated that the catecholamine released from neural and not neural cells could be affected characteristics of MSCs. However, there have not been review studies of most aspects involved in catecholamines-mediated functions of MSCs. Thus, in this review paper, we will try to describe the current state of catecholamines in MSCs destination and discuss strategies being used for catecholamines for migration of these cells to damaged tissues. Then, the role of the nervous system in the induction of osteogenesis, adipogenesis, chondrogenesis and myogenesis from MSCs is discussed. Recent progress in studies of signaling transduction of catecholamines in determination of the final fate of MSCs is highlighted. Hence, the knowledge of interaction between MSCs with the neural system could be applied towards the development of new diagnostic and treatment alternatives for human diseases.

Keywords

Mesenchymal stem cell Differentiation Catecholamines Adrenergic signaling Migration 

Abbreviations

ATF4

Activating transcription factor 4

BARK

β-Adr kinase

BM

Bone marrow

BMSCs

Bone marrow stem cells

BMP4

Bone morphogenetic proteins

C/EBP

CCAAT/enhancer-binding protein

DBH

Dopamine-b-Hydroxylase

DEHP

Bis (2-Ethylhexyl) phthalate

Ebf1

Early B-cell factor 1

EPAC

Exchange protein activated by adenylyl cyclase

EPO

Erythropoietin

FGF

Fibroblast growth factor

GPC

Growth plate chondrocytes

GPCRs

G-protein-coupled receptors

GCs

Glucocorticoids

HGF

Hepatocyte growth factor

HSCs

Hematopoietic stem cells

IGF-1

Insulin-like growth factor-1

IRFs

Interferon regulatory factors

MAFbx

Muscle atrophy F-box protein

MKP-1

Mitogen-activated protein kinase phosphatase

MSCs

Mesenchymal stem cells

MuRF1

Muscle ring finger1

OGP

Osteogenic growth peptide

PB

Peripheral blood

PDEs

Phosphodiesterase proteins

PGE2

Prostaglandin E2

pRb

Retinoblastoma cell cycle-related proteins

PKA

Protein kinase A

ROS

Reactive oxygen species

SDF-1

Stromal-derived factor-1

SHH

Sonic Hedgehog protein

SNS

Sympathetic nervous system

SREBPs

Sterol regulatory element binding proteins

S1P

Sphingosine1-phosphate

TBT

Tributyltin

TB4

Thymosin β

TF

Transcription factors

TH

Tyrosine hydroxylase

TGF-β

Transforming growth factor-β

TLR-9

Toll-like receptor 9

4EBP1

eIF4E binding protein1

Notes

Acknowledgments

We would like to acknowledge Thomas J. Kelly for his revisions and thank all our colleagues at the Department of Hematology in Tarbiat Modares University for assistance with the manuscript. This study was supported by Tarbiat Modares University.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Abbas Hajifathali
    • 1
  • Fakhredin Saba
    • 2
  • Amir Atashi
    • 2
  • Masoud Soleimani
    • 2
  • Esmaeil Mortaz
    • 3
  • Mahsa Rasekhi
    • 4
  1. 1.Bone Marrow Transplantation Center, Taleghani HospitalShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of Hematology, Faculty of Medical SciencesTarbiat Modares UniversityTehranIran
  3. 3.Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of ScienceUtrecht UniversityUtrechtThe Netherlands
  4. 4.Department of Molecular GeneticsNational Institute for Genetic Engineering and BiotechnologyTehranIran

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