Abstract
Central nervous system (CNS) development is driven by coordinated actions of developmental signals and chromatin regulators that precisely regulate gene expression patterns. Histone methylation is a regulatory mechanism that controls transcriptional programs. In the last 10 years, several histone demethylases (HDM) have been identified as important players in neural development, and their implication in cell fate decisions is beginning to be recognized. Identification of the physiological roles of these enzymes and their molecular mechanisms of action will be necessary for completely understanding the process that ultimately generates different neural cells in the CNS. In this review, we provide an overview of the Jumonji family of HDMs involved in neurodevelopment, and we discuss their roles during neural fate establishment and neuronal differentiation.
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We would like to acknowledge the contributions of the researchers in this field, which could not be cited here due to space limitations. This work was supported by grants (BFU2009-11527, BFU-2012-34261) from the Spanish MINECO, a grant (090210) from the Fundaciò La Marató de TV3, and a grant from the Fondation Jérôme Lejeune. A.G. received an FPU fellowship.
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During the consideration of the review it has been demonstrated that UTY(KDM6C) catalyses demethylation of H3K27 peptides in vitro, analogously to KDM6B and KDM6A.
Raquel Fueyo and María Alejandra García are equally contributing authors
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Fueyo, R., García, M.A. & Martínez-Balbás, M.A. Jumonji family histone demethylases in neural development. Cell Tissue Res 359, 87–98 (2015). https://doi.org/10.1007/s00441-014-1924-7
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DOI: https://doi.org/10.1007/s00441-014-1924-7