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Cell and Tissue Research

, Volume 356, Issue 3, pp 477–493 | Cite as

Sensing cellular states—signaling to chromatin pathways targeting Polycomb and Trithorax group function

  • Addie Kolybaba
  • Anne-Kathrin Classen
Review

Abstract

Cells respond to extra- and intra-cellular signals by dynamically changing their gene expression patterns. After termination of the original signal, new expression patterns are maintained by epigenetic DNA and histone modifications. This represents a powerful mechanism that enables long-term phenotypic adaptation to transient signals. Adaptation of epigenetic landscapes is important for mediating cellular differentiation during development and allows adjustment to altered environmental conditions throughout life. Work over the last decade has begun to elucidate the way that extra- and intra-cellular signals lead to changes in gene expression patterns by directly modulating the function of chromatin-associated proteins. Here, we review key signaling-to-chromatin pathways that are specifically thought to target Polycomb and Trithorax group complexes, a classic example of epigenetically acting gene silencers and activators important in development, stem cell differentiation and cancer. We discuss the influence that signals triggered by kinase cascades, metabolic fluctuations and cell-cycle dynamics have on the function of these protein complexes. Further investigation into these pathways will be important for understanding the mechanisms that maintain epigenetic stability and those that promote epigenetic plasticity.

Keywords

Polycomb/Trithorax Epigenetic Kinase signaling Metabolism Cell cycle 

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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Ludwig Maximilians University Munich, Faculty of BiologyPlanegg-MartinsriedGermany

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