Protein tyrosine phosphatase interacting protein 51—a jack-of-all-trades protein
Protein tyrosine phosphatase interacting protein 51 (PTPIP51) interacts both in vitro and in vivo with PTP1B, a protein tyrosine phosphatase involved in cellular regulation. PTPIP51 is known to be expressed in many different types of tissues. It is involved in cellular processes such as proliferation, differentiation and apoptosis. Nevertheless, the exact cellular function of PTPIP51 is still unknown. The present review summarizes our current knowledge of the PTPIP51 gene and its mRNA and protein structure.
KeywordsPTPIP51 Gene regulation mRNA structure Protein domains Isoforms
- Bobrich M, Brobeil A, Mooren FC, Krüger K, Steger K, Wimmer M (2011) PTPIP51 interaction with PTP1B and 14-3-3beta in adipose tissue of insulin resistant mice. Int J Obes (Lond) [Epub ahead of print]Google Scholar
- Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O’Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004) Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol 14:1436–1450PubMedCrossRefGoogle Scholar
- Stenzinger A, Schreiner D, Pfeiffer T, Tag C, Hofer HW, Wimmer M (2006) Epidermal growth factor-, transforming growth factor-beta-, retinoic acid- and 1, 25-dihydroxyvitamin D3-regulated expression of the novel protein PTPIP51 in keratinocytes. Cells Tissues Organs 184:76–87PubMedCrossRefGoogle Scholar
- Stenzinger A, Märker D, Koch P, Hoffmann J, Baal N, Steger K, Wimmer M (2009a) Protein tyrosine phosphatase interacting protein 51 (PTPIP51) mRNA expression and localization and its in vitro interacting partner protein tyrosine phosphatase 1B (PTP1B) in human placenta of the first, second, and third trimester. J Histochem Cytochem 57:143–153CrossRefGoogle Scholar
- Zhang X, Odom DT, Koo SH, Conkright MD, Canettieri G, Best J, Chen H, Jenner R, Herbolsheimer E, Jacobsen E, Kadam S, Ecker JR, Emerson B, Hogenesch JB, Unterman T, Young RA, Montminy M (2005) Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues. Proc Natl Acad Sci USA 102:4459–4464PubMedCrossRefGoogle Scholar