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Family of CNP neuropeptides: common morphology in various invertebrates

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Abstract

Neuropeptides expressed in the command neurons for withdrawal behavior were originally detected in the the central nervous system (CNS) of the terrestrial snail Helix (command neurons peptides, CNP). The family of CNP-like neuropeptides bears a C-terminal signature sequence Tyr-Pro-Arg-X. Using antisera against two of them, we have studied the CNS of various invertebrates belonging to the phyla of mollusks, annelids and insects. The immunoreactive neurons were detected in all studied species. Stained neurons were either interneurons projecting along the CNS ganglia chain, or sensory neurons, or neurohormonal cells. Beyond common morphological features, the immunoreactive cells had another similarity: the level of CNP expression depended on the functional state of the animal. Thus, the homologous neuropeptides in evolutionary distant invertebrate species possess some common morphological and functional features.

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Acknowledgements

The work was supported by Russian Foundation for Basic Research grants 09-04-00617-a, 08-04-00446a, grant of the RF President Council for Grants to P.M.B., Russian Academy of Sciences Program, Program of Ministery of Education and Science “Scientific and Educational Staff of Innovative Russia”.

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  1. Institute of Higher Nervous Activity and Neurophysiology RAS, 5A Butlerova Str, Moscow, 117485, Russia

    Victor N. Ierusalimsky & Pavel M. Balaban

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  1. Victor N. Ierusalimsky
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Correspondence to Victor N. Ierusalimsky.

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Ierusalimsky, V.N., Balaban, P.M. Family of CNP neuropeptides: common morphology in various invertebrates. Cell Tissue Res 343, 483–497 (2011). https://doi.org/10.1007/s00441-010-1119-9

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