Cell and Tissue Research

, Volume 343, Issue 2, pp 289–302 | Cite as

Osteoblast physiology in normal and pathological conditions

  • Anna Neve
  • Addolorata Corrado
  • Francesco Paolo CantatoreEmail author


Osteoblasts are mononucleated cells that are derived from mesenchymal stem cells and that are responsible for the synthesis and mineralization of bone during initial bone formation and later bone remodelling. Osteoblasts also have a role in the regulation of osteoclast activity through the receptor activator of nuclear factor κ-B ligand and osteoprotegerin. Abnormalities in osteoblast differentiation and activity occur in some common human diseases such as osteoporosis and osteoarthritis. Recent studies also suggest that osteoblast functions are compromised at sites of focal bone erosion in rheumatoid arthritis.


Osteoblasts Wnt/β-catenin pathway RANK/RANKL/OPG Osteoporosis Osteoarthritis Rheumatoid arthritis 


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Copyright information

© Springer-Verlag 2010

Authors and Affiliations

  • Anna Neve
    • 1
  • Addolorata Corrado
    • 1
  • Francesco Paolo Cantatore
    • 1
    • 2
    Email author
  1. 1.Rheumatology Clinic, Department of Medical and Occupational SciencesUniversity of FoggiaFoggiaItaly
  2. 2.Rheumatology ClinicUniversity of FoggiaFoggiaItaly

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