Cell and Tissue Research

, Volume 331, Issue 1, pp 1–3 | Cite as

Stem cells: established facts, open issues, and future directions

  • G. Kuhn
  • O. Brüstle
  • U. Martens
  • A. Wobus
  • K. UnsickerEmail author


The most recent Special Issue of Cell and Tissue Research addresses stem cells, probably one of the most exciting topics in current biology. The guest editors of this volume have put together recent advances and perspectives in four important fields of stem cell research: (1) embryonic stem cells, (2) somatic stem cells, (3) neural stem cells, and (4) stem cell therapy. Naturally, neural stem cells are a subclass of somatic stem cells. Nevertheless, because of the recent advances in this field, a separate category for neural stem cells was created. The section on stem cell therapy deals with embryonic and somatic stem cells and their potential therapeutic applications.

Embryonic stem cells

Embryonic stem cells are pluripotent cells with the capacity to give rise to every somatic cell type. Mechanisms underlying pluripotency include conserved regulatory networks composed of numerous transcription factors and signaling cascades described in the article by Yamanaka and...


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • G. Kuhn
    • 2
  • O. Brüstle
    • 3
  • U. Martens
    • 4
  • A. Wobus
    • 5
  • K. Unsicker
    • 1
    Email author
  1. 1.Neuroanatomy and Interdisciplinary Center for NeurosciencesUniversity of HeidelbergHeidelbergGermany
  2. 2.Institute of Neurosciences and PhysiologyUniversity of GöttingenGöttingenGermany
  3. 3.Institute of Reconstructive NeurobiologyUniversity of BonnBonnGermany
  4. 4.Department of Hematology/OncologyUniversity of FreiburgFreiburgGermany
  5. 5.Leibniz InstituteGaterslebenGermany

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