Cell and Tissue Research

, Volume 331, Issue 1, pp 165–178 | Cite as

Radial glia and neural stem cells

  • Paolo MalatestaEmail author
  • Irene Appolloni
  • Filippo Calzolari


During the last decade, the role of radial glia has been radically revisited. Rather than being considered a mere structural component serving to guide newborn neurons towards their final destinations, radial glia is now known to be the main source of neurons in several regions of the central nervous system, notably in the cerebral cortex. Radial glial cells differentiate from neuroepithelial progenitors at the beginning of neurogenesis and share with their ancestors the bipolar shape and the expression of some molecular markers. Radial glia, however, can be distinguished from neuroepithelial progenitors by the expression of astroglial markers. Clonal analyses showed that radial glia is a heterogeneous population, comprising both pluripotent and different lineage-restricted neural progenitors. At late-embryonic and postnatal stages, radial glial cells give rise to the neural stem cells responsible for adult neurogenesis. Embryonic pluripotent radial glia and adult neural stem cells may be clonally linked, thus representing a lineage displaying stem cell features in both the developing and mature central nervous system.


Neural progenitors Ventricular zone Lineage tracing Neurogenesis Gliogenesis 



We would like to acknowledge Prof. M. Götz for helpful comments on the manuscript.


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Copyright information

© Springer-Verlag 2007

Authors and Affiliations

  • Paolo Malatesta
    • 1
    • 2
    Email author
  • Irene Appolloni
    • 1
    • 2
  • Filippo Calzolari
    • 1
    • 2
  1. 1.Dipartimento di Oncologia, Biologia e GeneticaUniversità degli Studi di GenovaGenoaItaly
  2. 2.Istituto Nazionale per la Ricerca sul Cancro (IST), IRCCSGenoaItaly

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