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Ectopic localization of putative AII amacrine cells in the outer plexiform layer of the developing FVB/N mouse retina

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Abstract

The FVB/N mouse is a model of retinitis pigmentosa which shows a rapid loss of photoreceptors during early postnatal (P) life. We investigated the cellular localization of glycine transporter 1 (GlyT-1) in the developing FVB/N mouse retina. In control retinas, the developmental pattern of GlyT-1-immunoreactive amacrine cells was well in accordance with a previous report. However, in the FVB/N mouse retina, some GlyT-1-labeled amacrine cells sent their processes into the outer plexiform layer (OPL) from P14 onward. From P21 onward, GlyT-1-labeled cells were visible in the OPL. These cells were further characterized by double-label immunofluorescence experiments with an antiserum against disabled 1 (Dab-1), and showed Dab-1 immunoreactivity, indicating that these cells are putative AII amacrine cells. These results clearly demonstrate that AII amacrine cells have the potential capacity to respond to photoreceptor degeneration by migrating or sprouting their processes into the OPL in the developing FVB/N mouse retina.

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Acknowledgements.

We are grateful to Dr. C. Bowes Rickman at Duke University Eye Center for her valuable comments, and are thankful to Mr. Hee-Duck Rho and Hong-Lim Kim for their excellent technical assistance.

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Authors and Affiliations

  1. Department of Anatomy, College of Medicine, The Catholic University of Korea, 137-701, Seoul, Korea

    Sung-Jin Park, Eun-Jin Lim, Su-Ja Oh, Jin-Woong Chung & Myung-Hoon Chun

  2. Department of Ophthalmology and Neurobiology, Duke University, Erwin Road, Box 3802, Durham, NC 27710, USA

    Dennis W. Rickman

  3. Department of Ophthalmology, College of Medicine, The Catholic University of Korea, 137-701, Seoul, Korea

    Jung-Il Moon

Authors
  1. Sung-Jin Park
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  2. Eun-Jin Lim
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  3. Su-Ja Oh
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  4. Jin-Woong Chung
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  5. Dennis W. Rickman
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  6. Jung-Il Moon
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  7. Myung-Hoon Chun
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Correspondence to Myung-Hoon Chun.

Additional information

This study was supported by a Korea Research Foundation Grant (2001, PF0005) from the Ministry of Education

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Park, SJ., Lim, EJ., Oh, SJ. et al. Ectopic localization of putative AII amacrine cells in the outer plexiform layer of the developing FVB/N mouse retina. Cell Tissue Res 315, 407–412 (2004). https://doi.org/10.1007/s00441-003-0844-8

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  • DOI: https://doi.org/10.1007/s00441-003-0844-8

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