Elite endurance athletes and the ACE I allele – the role of genes in athletic performance

Abstract

Genetic markers that might contribute to the making of an elite athlete have not been identified. Potential candidate genes might be found in the renin-angiotensin pathway, which plays a key role in the regulation of both cardiac and vascular physiology. In this study, DNA polymorphisms derived from the angiotensin converting enzyme (ACE), the angiotensin type 1 receptor (AT1) and the angiotensin type 2 receptor (AT2) were studied in 64 Australian national rowers. Compared with a normal population, the rowers had an excess of the ACE I allele (P<0.02) and the ACE II genotype (P=0.03). The ACE I allele is a genetic marker that might be associated with athletic excellence. It is proposed that the underlying mechanism relates to a healthier cardiovascular system.

This is a preview of subscription content, access via your institution.

Author information

Affiliations

Authors

Additional information

Received: 20 October 1997 / Accepted: 10 March 1998

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Gayagay, G., Yu, B., Hambly, B. et al. Elite endurance athletes and the ACE I allele – the role of genes in athletic performance. Hum Genet 103, 48–50 (1998). https://doi.org/10.1007/s004390050781

Download citation

Keywords

  • Candidate Gene
  • Angiotensin
  • Cardiovascular System
  • Underlying Mechanism
  • Genetic Marker