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The human cornea has a high incidence of acquired chromosome abnormalities

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Abstract

Structurally and functionally, the human cornea is a highly specialized tissue. The corneal stromal collagen matrix is uniquely transparent and yet maintains a mechanically tough and chemically impermeable barrier between the eye and environment. We report for the first time that stromal keratocytes of the human cornea show cytogenetic abnormalities with a frequency that is unprecedented among normal tissues. The abnormalities are acquired, clonal and nonclonal, primarily aneuploid in nature, and present in normal as well as diseased corneas.

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Authors and Affiliations

  1. Department of Pediatrics, Section on Medical Genetics, Medical Center Blvd, Bowman Gray School of Medicine, Winston-Salem, NC 27157, USA Fax: 910-716-2554, , , , , , US

    M. J. Pettenati & P. Nagesh Rao

  2. Department of Ophthalmology, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC 27157, USA, , , , , , US

    Andrew J. Sweatt, Constance A. Stanton & Richard M. Davis

  3. Department of Pathology, Bowman Gray School of Medicine, Winston-Salem, NC 27157, USA, , , , , , US

    Patrick Lantz

  4. Shodair Hospital, Helena, MT 59604, USA, , , , , , SH

    James Reynolds

Authors
  1. M. J. Pettenati
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  2. Andrew J. Sweatt
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  3. Patrick Lantz
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  4. Constance A. Stanton
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  5. James Reynolds
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  6. P. Nagesh Rao
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  7. Richard M. Davis
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Additional information

Received: 10 February 1997 / Accepted: 21 May 1997

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Pettenati, M., Sweatt, A., Lantz, P. et al. The human cornea has a high incidence of acquired chromosome abnormalities. Hum Genet 101, 26–29 (1997). https://doi.org/10.1007/s004390050580

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  • DOI: https://doi.org/10.1007/s004390050580

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