Skip to main content

Transglutaminase activity is related to CAG repeat length in patients with Huntington’s disease

Human Genetics volume 98, pages 633–635 (1996)Cite this article

Abstract

Huntington’s disease (HD) is a neurodegenerative disorder associated with CAG repeat expansion. We measured transglutaminase (TGase) activity in lymphocytes from 35 HD patients and from healthy individuals to ascertain whether it was altered in this condition. TGase activity was above maximum control levels in 25% of HD patients; it was correlated with the age of the patient and inversely correlated with the CAG repeat length. These results suggest that: (1) HD could be biochemically heterogeneous, and (2) the length of the CAG repeat expansion/TGase ratio could be important in the manifestation of HD.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Author information

Affiliations

  1. Laboratorio di Biochimica e Biologia Molecolare, Stazione Zoologica “Anton Dohrn”, Villa Comunale, I-80121 Naples, Italy Tel.: +39-81-5833216; Fax: +39-81-7641355, IT

    L. Cariello, Laura Zanetti & Roberto Di Lauro

  2. Centro di Endocrinologia ed Oncologia Sperimentale (C.E.O.S.) del C.N.R c/o Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universita’ di Napoli Federico II, Via S. Pansini 5, I-80131 Naples, Italy, IT

    T. de Cristofaro & S. Varrone

  3. Dipartimento di Scienze Neurologiche, Universita’ di Napoli Federico II, Via S. Pansini 5, I-80131 Naples, Italy, IT

    Teresa Cuomo, Luigi Di Maio & Giuseppe Campanella

  4. Dipartimento di Matematica e Applicazioni, Universita’ di Napoli Federico II, Complesso Universitario Monte S.Angelo, Via Cintia, I-80126 Naples, Italy, IT

    Silvana Rinaldi

  5. Dipartimento di S.A.V.A., Universita’ del Molise, I-86100 Campobasso, Italy, IT

    Paolo Zanetti

Authors
  1. L. Cariello
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. de Cristofaro
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Laura Zanetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Teresa Cuomo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Luigi Di Maio
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Giuseppe Campanella
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Silvana Rinaldi
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Paolo Zanetti
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Roberto Di Lauro
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. S. Varrone
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received: 25 March 1996 / Revised: 23 June 1996

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Cariello, L., de Cristofaro, T., Zanetti, L. et al. Transglutaminase activity is related to CAG repeat length in patients with Huntington’s disease. Hum Genet 98, 633–635 (1996). https://doi.org/10.1007/s004390050273

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004390050273

Keywords

  • Healthy Individual
  • Control Level
  • Neurodegenerative Disorder
  • Repeat Length
  • Repeat Expansion