Abstract
Human rhinoviruses (RV) are a frequent cause of respiratory tract infections with substantial morbidity and mortality in some patients. Nevertheless, the genetic basis of susceptibility to RV in humans has been relatively understudied. Experimental infections of mice and in vitro infections of human cells have indicated that various pathogen recognition receptors (TLRs, RIG-I, and MDA5) regulate innate immune responses to RV. However, deficiency of MDA5 is the only one among these so far uncovered that confers RV susceptibility in humans. Other work has shown increased RV susceptibility in patients with a polymorphism in CDHR3 that encodes the cellular receptor for RV-C entry. Here, we provide a comprehensive review of the genetic determinants of human RV susceptibility in the context of what is known about RV biology.
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Acknowledgements
This work was supported by the Intramural Research Program of the National Institute of Allergy and Infectious Diseases, National Institutes of Health (Grant no. ZIAAI001059). On behalf of all authors, the corresponding author states that there is no conflict of interest. We thank Drs. Huie Jing and Yu Zhang for helpful comments.
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Lamborn, I.T., Su, H.C. Genetic determinants of host immunity against human rhinovirus infections. Hum Genet 139, 949–959 (2020). https://doi.org/10.1007/s00439-020-02137-3
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DOI: https://doi.org/10.1007/s00439-020-02137-3