Human Genetics

, Volume 136, Issue 10, pp 1375–1384 | Cite as

A genetic variant in the placenta-derived MHC class I chain-related gene A increases the risk of preterm birth in a Chinese population

  • Junjiao Song
  • Jing Li
  • Han Liu
  • Yuexin Gan
  • Yang Sun
  • Min Yu
  • Yongjun Zhang
  • Fei Luo
  • Ying Tian
  • Weiye Wang
  • Jun Zhang
  • Julian Little
  • Haidong Cheng
  • Dan Chen
Original Investigation

Abstract

Preterm birth (PTB) is a predominant contributor to neonatal mortality and morbidity worldwide. However, the pathophysiology of PTB is not well-understood. We tested the hypothesis that single-nucleotide polymorphisms (SNPs) in the placenta-derived MHC class I chain-related gene A (MICA) could disrupt placental development and hence result in PTB. Nineteen selected SNPs in MICA were genotyped in a case–control study of 127 premature infants and 634 term controls in a Chinese Han population. We found that significantly increased PTB risk was associated with homozygosity for the A variant of rs2256318 (adjusted odds ratio = 6.97 and 95% confidence interval = 2.34–20.74 for A/A, compared with G/G genotype, P = 0.001). In addition, the A/A genotype of rs2256318 was associated with decreased placental weight of neonates (β = −25.331; P = 0.033). Furthermore, stratified analysis demonstrated that the A/A genotype of rs2256318 was associated with increased PTB risk in female group. In addition, we observed statistical interaction between the polymorphism rs2516448 and sex (P = 0.04). No significant differences in the distribution of haplotypes between cases and controls were detected. Our results indicate that the polymorphism of rs2256318 in MICA may contribute to the etiology of PTB through interfering with placental development. These findings need to be further validated in larger and multi-ethnic populations.

Notes

Acknowledgements

Thank Dr. Julian Little for amending our manuscript. We acknowledge Shanghai birth cohort. This work was supported by the National Natural Science Foundation of China (NSFC) Grants (81401212), by Shanghai Youth Eastern Scholar (QD 2015006), and by Shanghai Pujiang Talent Project (15PJ1405500). Julian Little is holder of Canada Research Chair in Human Genome Epidemiology.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Supplementary material

439_2017_1834_MOESM1_ESM.doc (203 kb)
Supplementary material 1 (DOC 203 kb)

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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Junjiao Song
    • 1
  • Jing Li
    • 3
  • Han Liu
    • 1
  • Yuexin Gan
    • 1
  • Yang Sun
    • 2
  • Min Yu
    • 2
  • Yongjun Zhang
    • 1
  • Fei Luo
    • 4
  • Ying Tian
    • 1
  • Weiye Wang
    • 1
  • Jun Zhang
    • 1
  • Julian Little
    • 5
  • Haidong Cheng
    • 4
  • Dan Chen
    • 1
  1. 1.Ministry of Education and Shanghai Key Laboratory of Children’s Environmental HealthXin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina
  2. 2.Laboratory of Biochemistry and Molecular Biology, School of Life ScienceYunnan UniversityKunmingChina
  3. 3.Department of NeonatologyShanghai Children’s Medical Center Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina
  4. 4.Department of ObstetricsObstetrics and Gynecology Hospital of Fudan UniversityShanghaiChina
  5. 5.School of Epidemiology, Public Health and Preventive MedicineUniversity of OttawaOttawaCanada

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