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Human Genetics

, Volume 131, Issue 7, pp 1047–1056 | Cite as

Association of PDE4B polymorphisms and schizophrenia in Northwestern Han Chinese

  • Fanglin Guan
  • Chen Zhang
  • Shuguang Wei
  • Hongbo Zhang
  • Xiaomin Gong
  • Jiali Feng
  • Chengge Gao
  • Rong Su
  • Huanming Yang
  • Shengbin LiEmail author
Original Investigation

Abstract

The phosphodiesterase 4B (PDE4B) is a candidate susceptibility gene for schizophrenia (SCZ), interacting with DISC1, a known genetic risk factor for SCZ. To examine if variants within PDE4B gene are associated with SCZ in Northwestern Han Chinese, and if these effects vary in gender-specific subgroup, we analyzed 20 SNPs, selected from previous studies and preliminary HapMap data analyses with minor allele frequency (MAF) ≥20%, in a cohort of 428 cases and 572 controls from genetically independent Northwestern Han Chinese. Single SNP association, haplotype association and sex-specific association analysis were performed. We found that rs472952 is significantly associated with SCZ and rs7537440 is associated with SCZ in females. Further analysis indicated that a haplotype block spanning PDE4B2 splice site is highly associated with SCZ and several haplotypes in this block have about twofold to threefold increase in cases. Our results provide further evidence that PDE4B may play important roles in the etiology of SCZ.

Keywords

Haplotype Block Risk Haplotype Haplotype Association Analysis PDE4B Gene Extra Cellular Signal Regulate Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank all of the donors for their assistance in accessing collections and their advice and comments during the preparation of this paper.

Supplementary material

439_2011_1120_MOESM1_ESM.doc (310 kb)
Supplementary material 1 (DOC 310 kb)

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Copyright information

© Springer-Verlag 2011

Authors and Affiliations

  • Fanglin Guan
    • 1
  • Chen Zhang
    • 2
  • Shuguang Wei
    • 3
  • Hongbo Zhang
    • 1
  • Xiaomin Gong
    • 3
  • Jiali Feng
    • 1
  • Chengge Gao
    • 4
  • Rong Su
    • 3
  • Huanming Yang
    • 5
  • Shengbin Li
    • 6
    Email author
  1. 1.Key Laboratory of Environment and Genes Related to DiseasesMinistry of EducationXi’anChina
  2. 2.The First Department of Orthopedics, The Second Affiliated Hospital, College of MedicineXi’an Jiaotong UniversityXi’anChina
  3. 3.Key Laboratory of National Ministry of Health for Forensic Sciences, College of MedicineXi’an Jiaotong UniversityXi’anChina
  4. 4.Department of Psychiatry, The First Affiliated Hospital, College of MedicineXi’an Jiaotong UniversityXi’anChina
  5. 5.Beijing Genomics InstituteShenzhenChina
  6. 6.Institute of Human Genomics and Forensic SciencesXi’anChina

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