Erratum to: Evidence of statistical epistasis between DISC1, CIT and NDEL1 impacting risk for schizophrenia: biological validation with functional neuroimaging

Erratum to: Hum Genet DOI 10.1007/s00439-009-0782-y

Authors regret that Figs. 2 and 3 labeling in the online published article, color indication for graph bars “Non-risk” and “Risk” were inadvertently swapped. The corrected figures are given below.

Fig. 2

CIT intragenic neuroimaging epistasis. CIT rs3847960 by CIT rs440299 interaction in normal subjects studied with BOLD fMRI during the N back working memory task. Figure at the top shows loci (in yellow) within brain in which significant interaction is found (p < 0.05 corrected) for all voxels within prefrontal cortical region of interest. Image at bottom shows relative degree of activation of DLPFC region showing imaging interaction based on genotypes at these two SNPs [fMRI signal extracted from maximum voxel and run as ANOVA in SPSS yielded F(1,256) = 9.960, p = 0.002]. The combination of both risk associated genotypes is disproportionally inefficient, i.e., have greatest activation without any difference in performance. Error bars represent 1 standard error of the mean. Frontal lobe (sub-gyral) mean activation extracted from 10 mm sphere at (30 37 8) Talairach

Fig. 3

DISC1 by CIT neuroimaging epistasis. DISC1 rs1411771 by CIT rs10744743 interaction in 217 normal subjects studied with BOLD fMRI during the N-back working memory task. The cross-sectional brain images at top figure show loci (in yellow) within brain showing a significant inefficiency effect associated with DISC1 risk × CIT risk SNPs (p < 0.05 small volume correction SVC). The graph at bottom compares a measure of fMRI activation during this task for each genotype combination extracted from right PFC yielding a significant epistatic interaction [fMRI signal extracted from maximum voxel and run as ANOVA in SPSS yielded F(1,213) = 5.3 p < 0.05]