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Human Genetics

, Volume 126, Issue 5, pp 677–683 | Cite as

Familial autosomal dominant reflex epilepsy triggered by hot water maps to 4q24-q28

  • Rinki Ratnapriya
  • Parthasarthy Satishchandra
  • S. Dilip
  • Girish Gadre
  • Anuranjan Anand
Original Investigation

Abstract

Hot water epilepsy is a reflex or sensory epilepsy in which seizures are triggered by the stimulus of bathing in hot water. Although there is evidence of a genetic basis to its etiology, no gene associated with this disorder has so far been found. In order to identify the genetic locus involved in the pathophysiology of hot water epilepsy, we performed a genome-wide linkage analysis in a four-generation family manifesting the disorder in an autosomal dominant manner. Significant linkage was detected on chromosome 4q24-q28, with the highest two-point LOD score of 3.50 at recombination value (θ) of 0 for the marker D4S402. Centromere-proximal and centromere-distal boundaries of this locus were defined by the markers D4S1572 and D4S2277, respectively. The critical genetic interval spans 22.5 cM and corresponds to about 24 megabases of DNA. The genes NEUROG2, ANK2, UGT8 and CAMK2D, which are known to be expressed in human brain, are strong positional candidates and we propose to examine these and other genes in the locus to identify the causative gene for this intriguing form of epilepsy.

Keywords

Febrile Seizure Clobazam Audiogenic Seizure Genetic Interval Dravet Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

We thank all the family members for participation in the study. We thank Sharat Chandra and Prakash for critical reading and comments on the manuscript. RR acknowledges receipt of a research fellowship from CSIR, New Delhi. This work was supported by funds from DAE, Mumbai; ICMR, New Delhi and JNCASR, Bangalore.

Conflict of interest statement

All authors report no financial interests or potential conflicts of interests.

Supplementary material

439_2009_718_MOESM1_ESM.doc (66 kb)
Supplementary Table 1 (DOC 66 kb)
439_2009_718_MOESM2_ESM.doc (102 kb)
Supplementary Table 2 (DOC 102 kb)

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Copyright information

© Springer-Verlag 2009

Authors and Affiliations

  • Rinki Ratnapriya
    • 1
  • Parthasarthy Satishchandra
    • 2
  • S. Dilip
    • 2
  • Girish Gadre
    • 2
  • Anuranjan Anand
    • 1
  1. 1.Molecular Biology and Genetics UnitJawaharlal Nehru Centre for Advanced Scientific ResearchBangaloreIndia
  2. 2.Department of NeurologyNational Institute of Mental Health and NeurosciencesBangaloreIndia

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