A strong association between human earwax-type and apocrine colostrum secretion from the mammary gland
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Here we provided the first genetic evidence for an association between the degree of apocrine colostrum secretion and human earwax type. Genotyping at the earwax-type locus, rs17822931 within the ABCC11 gene, revealed that 155 of 225 Japanese women were dry-type and 70 wet-type. Frequency of women without colostrum among dry-type women was significantly higher than that among wet-type women (P < 0.0002), and the measurable colostrum volume in dry-type women was significantly smaller than in wet-type women (P = 0.0341).
KeywordsHuman earwax-type Colostrum secretion ABCC11 Polymorphism
We thank the volunteer women for their participation in this study, midwives in Nagasaki University Hospital for their assistance to measure the colostrums, and Dr. Joseph Wagstaff for his help and valuable advice. H. M. and N. N. were supported in part by Grants-in-Aid for Scientific Research (Nos. 17591748 and 17019055, respectively) from the Ministry of Education, Sports, Culture, Science and Technology of Japan.
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