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Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations

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Abstract

SOD2 (superoxide dismutase 2) plays a crucial role in protecting the cells against damage caused by free radicals, by catalyzing their detoxification. On the other hand, cell damage caused by free radical generation following methamphetamine administration has been postulated as one of the possible pathophysiological mechanisms for methamphetamine psychosis. Hence, we investigated the association of SOD2 polymorphisms with the development of methamphetamine psychosis, in two independent populations of Japan and Taiwan. We recruited 116 patients with methamphetamine psychosis and 189 controls in Japan, and 135 patients with methamphetamine psychosis and 204 controls in Taiwan. The methamphetamine group was divided into two clinical subtypes: a transient type of psychosis (i.e., good prognosis) and a prolonged type of psychosis (i.e., poor prognosis), according to the course of the manifestation of psychosis. With reference to the genotypic and allelic frequencies of Ala/Val functional polymorphism in exon 2, we found significant differences between individuals with prolonged methamphetamine psychosis and control samples from Japan and Taiwan in the genotypic (P value 0.014 and 0.016, respectively) and in the allelic (P value 0.004 and 0.047, respectively) frequencies. Our results suggest that Ala/Val polymorphism of the SOD2 gene could be associated with the risk of developing methamphetamine psychosis.

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Acknowledgments

This work was supported by Grant-in-Aid for Scientific Reseach (A) from the Ministry of Education Science, Sports and Culture of Japan and grant from Stanley Foundation. Recruitment of Taiwanese sample was supported by research grants from the Chang Gung Memorial Hospital, Taiwan and the National Science Council, Taiwan. We thank Osada Naoko and Kamahori Naomi for technical assistance.

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Authors and Affiliations

  1. Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Hamamatsu, 431-3192, Japan

    Kazuhiko Nakamura, Yoshimoto Sekine, Yasuhide Iwata, A. Anitha, Nori Takei, Atsuko Suzuki, Masayoshi Kawai, Kiyokazu Takebayashi, Katsuaki Suzuki, Yoshio Minabe, Kenji Tsuchiya & Norio Mori

  2. Department of Psychiatry, Chang Gung Memorial Hospital, Taipei, Taiwan

    Chih-Ken Chen

  3. Japanese Genetics Initiative for Drug Abuse, Okayama, Japan

    Yoshimoto Sekine, Masaomi Iyo, Norio Ozaki, Toshiya Inada, Nakao Iwata, Mutsuo Harano, Tokutaro Komiyama, Mitsuhiko Yamada, Ichiro Sora & Hiroshi Ujike

  4. Division of Mental Health and Drug Abuse Research, National Health Research Institutes, Taipei, Taiwan

    El-Wui Loh

  5. Laboratory of Molecular Psychiatry, RIKEN Brain Science Institute, Saitama, Japan

    Kazuo Yamada & Takeo Yoshikawa

  6. Department of Psychiatry, Graduate School of Medicine, Chiba University, Chiba, Japan

    Masaomi Iyo

  7. Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan

    Norio Ozaki

  8. Department of Psychiatry, Teikyo University School of Medicine Ichihara Hospital, Chiba, Japan

    Toshiya Inada

  9. Department of Psychiatry, Fujita Health University School of Medicine, Aichi, Japan

    Nakao Iwata

  10. Department of Neuropsychiatry, Kurume University School of Medicine, Kurume, Japan

    Mutsuo Harano

  11. Division of Psychiatry, National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan

    Tokutaro Komiyama

  12. Department of Psychogeriatrics, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan

    Mitsuhiko Yamada

  13. Department of Neuroscience, Division of Psychobiology, Tohoku University Graduate School of Medicine, Sendai, Japan

    Ichiro Sora

  14. Department of Neuropsychiatry, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan

    Hiroshi Ujike

  15. Division of Psychological Medicine, Institute of Psychiatry, University of London, London, UK

    David M. Ball

  16. Department of Psychiatry, Taipei City Psychiatric Center, Taipei, Taiwan

    Shih-Ku Lin

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  1. Kazuhiko Nakamura
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  2. Chih-Ken Chen
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  3. Yoshimoto Sekine
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  8. Atsuko Suzuki
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  9. Masayoshi Kawai
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  10. Kiyokazu Takebayashi
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  11. Katsuaki Suzuki
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  12. Yoshio Minabe
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  13. Kenji Tsuchiya
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  14. Kazuo Yamada
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  15. Masaomi Iyo
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  16. Norio Ozaki
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  17. Toshiya Inada
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  18. Nakao Iwata
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  19. Mutsuo Harano
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  20. Tokutaro Komiyama
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  21. Mitsuhiko Yamada
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  22. Ichiro Sora
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  23. Hiroshi Ujike
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  24. David M. Ball
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  25. Takeo Yoshikawa
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  26. Shih-Ku Lin
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  27. Norio Mori
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Corresponding author

Correspondence to Kazuhiko Nakamura.

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Nakamura, K., Chen, CK., Sekine, Y. et al. Association analysis of SOD2 variants with methamphetamine psychosis in Japanese and Taiwanese populations. Hum Genet 120, 243–252 (2006). https://doi.org/10.1007/s00439-006-0189-y

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  • DOI: https://doi.org/10.1007/s00439-006-0189-y

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