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DNA sequence variation of the human ABO-secretor locus (FUT2) in New Guinean populations: possible early human migration from Africa

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Abstract

We have investigated the allelic polymorphism of the human ABO-secretor locus (FUT2) in 90 unrelated Papuan-speaking New Guineans (Dani group), 101 admixed New Guineans from Irian Jaya, Indonesia, and 32 New Guineans from Papua New Guinea by DNA sequencing analysis. Whereas the total frequency of various nonfunctional alleles at the FUT2 locus in the worldwide populations so far examined is around 0.5, we have found only one individual heterozygous for a nonfunctional allele in the 90 Dani group members and a frequency of nonfunctional alleles of 0.1–0.2 in the admixed New Guineans. Admixed New Guineans had the Asian-specific null allele se 385 and the characteristic nonfunctional allele se del2 found in Polynesians. In addition, both New Guinean populations had unique functional alleles (Se 375 and Se 400) with high frequencies (0.11–0.37); these are absent in other populations of the world except for African and Samoan populations. The Se 375 allele had G and C at positions 1009 and 1011 of the 3' untranslated region, respectively, whereas all other FUT2 alleles found so far in the world, except for se 428, have 1009A and 1011T. The Se 375 allele found in Africans has 1009G and 1011T, or 1009A and 1011T. Corresponding positions of nonhuman primates have G and C, suggesting that the Se 375 allele is one of the ancestral alleles, reflecting the early human migration from Africa to New Guinea and the long isolation of Dani populations from neighboring populations.

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Acknowledgements

This work was supported in part by Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Culture and Sports of Japan. H. T. was supported by a Grant-in-Aid for Scientific Research on Priority Areas ''Medical Genome Science'' no. 15012239. We thank Mr. S. Kamimura and Miss Y. Noguchi for technical assistance.

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Authors and Affiliations

  1. Division of Human Genetics, Department of Forensic Medicine, Kurume University School of Medicine, 830-0011, Kurume, Japan

    Yoshiro Koda, Baojie Wang, Hao Pang, Mikiko Soejima & Hiroshi Kimura

  2. Department of Anthropology, Unit of Human Biology and Genetics, Faculty of Science, University of Tokyo, Hongo, 113-0033, Tokyo, Japan

    Takafumi Ishida

  3. Department of Biology, Faculty of Sciences, Kyushu University, 812-8581, Fukuoka, Japan

    Hidenori Tachida

  4. Department of Serology, Faculty of Forensic Medicine, China Medical University, 11001, Shenyang, China

    Baojie Wang & Hao Pang

  5. Faculty of Medicine, Diponegoro University, Semarang, Indonesia

    Augustinus Soemantri

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  1. Yoshiro Koda
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  2. Takafumi Ishida
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Correspondence to Yoshiro Koda.

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Koda, Y., Ishida, T., Tachida, H. et al. DNA sequence variation of the human ABO-secretor locus (FUT2) in New Guinean populations: possible early human migration from Africa. Hum Genet 113, 534–541 (2003). https://doi.org/10.1007/s00439-003-1013-6

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