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Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection

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Abstract.

We investigated the occurrence of the CCR5Δ32 mutation in various regional ethnic groups in Brazil and tested the resistance of mutant peripheral blood mononuclear cells (PBMCs) to infection by HIV-1 in vitro. The heterozygous prevalence was 5.3% in uninfected African descendents and 8.8% in HIV-1-positive individuals (neither population had Δ32/Δ32). German descendents were 11% heterozygous and l% Δ32/Δ32. Amerindians were exclusively CCR5/CCR5. Heterozygous uninfected PBMCs showed partial resistance to R5-HIV-1 strains in vitro, but no resistance to X4 virus. HIV-1-positive CCR5/CCR5 had higher viral loads than did heterozygous cells.

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Authors and Affiliations

  1. Laboratório Avançado de Saúde Pública, Centro de Pesquisas Gonçalo Moniz/FIOCRUZ – Rua Waldemar Falcão 121, Brotas, Salvador-BA, Brasil. CEP: 40.295–001, Brasil

    Rogério Grimaldi, Nice Shindo, Angelina Acosta, Dumith Bou-Habib & Bernardo Galvão-Castro

  2. Instituto de Saúde Coletiva / Universidade Federal da Bahia, Salvador-Bahia, Brazil, Brasil

    Inês Dourado

  3. Hospital Universitário Professor Edgar Santos/Universidade Federal da Bahia, Salvador-Bahia, Brasil, Brasil

    Carlos Brites

  4. Hemocentro Regional de Joinville, Secretaria de Estado da Saúde, Santa Catarina, Brasil, Brasil

    Ozenilda de Melo Carvalho

  5. Programa Nacional de Controle de DST/AIDS, Ministério da Saúde, Brasília, Brasil, Brasil

    Ivo Brito

Authors
  1. Rogério Grimaldi
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  2. Nice Shindo
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  3. Angelina Acosta
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  4. Inês Dourado
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  5. Carlos Brites
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  6. Ozenilda de Melo Carvalho
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  7. Ivo Brito
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  8. Dumith Bou-Habib
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  9. Bernardo Galvão-Castro
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Grimaldi, R., Shindo, N., Acosta, A. et al. Prevalence of the CCR5Δ32 mutation in Brazilian populations and cell susceptibility to HIV-1 infection. Hum Genet 111, 102–104 (2002). https://doi.org/10.1007/s00439-002-0747-x

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  • DOI: https://doi.org/10.1007/s00439-002-0747-x

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