Abstract
The dominant Drosophila wing mutation Dichaete is characterised by the deletion of proximal wing structures. By analysing a number of new Dichaete alleles, phenotypic revertants and enhancer piracy lines, we show that the wing phenotype results from ectopic expression of the Sox-domain gene Dichaete. Ectopic expression of the Sox gene results in an increase in cell death in the proximal region of the wing imaginal disc and leads to alterations in the normal expression of wingless. Since ectopic expression of wingless in the proximal region of the wing disc can rescue aspects of the Dichaete phenotype, it is likely that Dichaete specifically interferes with the establishment or maintenance of a critical domain of wingless expression in the wing disc.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 20 January 2000 / Accepted: 14 February 2000
Rights and permissions
About this article
Cite this article
Russell, S. The Drosophila dominant wing mutation Dichaete results from ectopic expression of a Sox-domain gene. Mol Gen Genet 263, 690–701 (2000). https://doi.org/10.1007/s004380051218
Issue Date:
DOI: https://doi.org/10.1007/s004380051218