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Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1

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Abstract

ORC1 encodes a subunit of the eukaryotic origin recognition complex in yeast, which has been shown to play a crucial role in chromosomal DNA replication and transcriptional silencing. We have identified a mouse protein closely related to Saccharomyces cerevisiae ORC1 as well as to the human, Xenopus and Drosophila homologs. MmORC1 has putative cyclin-dependent phosphorylation sites and a nucleotide triphosphate-binding motif. We have mapped the gene locus of the murine Orc1 gene to chromosome 4, band D. Conservation of structures among members of the ORC1-related proteins suggests that these proteins play a key role in the intiation of DNA replication in all eukaryotes.

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Authors and Affiliations

  1. Institute of Biochemistry, Biozentrum, University of Würzburg D-97074 Würzburg, Germany e-mail: grummt@biozentrum.uni-wuerzburg.de Tel.:+49-931-888-4042, Fax:+49-931-888-4045, , , , , , DE

    P. Zisimopoulou, C. Staib & F. Grummt

  2. Institute of Human Genetics, Biozentrum University of Würzburg, D-97074 Würzburg, Germany, , , , , , DE

    I. Nanda & M. Schmid

Authors
  1. P. Zisimopoulou
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  2. C. Staib
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  3. I. Nanda
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  4. M. Schmid
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  5. F. Grummt
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Received: 1 July 1998 / Accepted: 18 August 1998

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Zisimopoulou, P., Staib, C., Nanda, I. et al. Mouse homolog of the yeast origin recognition complex subunit ORC1 and chromosomal localization of the cognate mouse gene Orc1 . Mol Gen Genet 260, 295–299 (1998). https://doi.org/10.1007/s004380050898

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  • DOI: https://doi.org/10.1007/s004380050898

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