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Effect of IciA protein on the expression of the nrd gene encoding ribonucleoside diphosphate reductase in E. coli

Molecular and General Genetics MGG volume 259, pages 610–614 (1998)Cite this article

Abstract

The E. coli nrd operon contains the genes encoding the two subunits of ribonucleoside diphosphate reductase. We found that the IciA protein binds specifically to the AT-rich upstream region of nrd promoter. In vivo overexpression of IciA increases the expression of nrd gene by four- to five-fold, suggesting that IciA functions as a transcriptional activator for the nrd gene.

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Affiliations

  1. Institute for Molecular Biology and Genetics, Seoul National University, Seoul 151–742, Korea Fax: +82-2-874-1206 E-mail: dshwang@plaza.snu.ac.kr, KR

    J. S. Han, H. S. Kwon, J.-B. Yim & D. S. Hwang

Authors
  1. J. S. Han
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  2. H. S. Kwon
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  3. J.-B. Yim
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  4. D. S. Hwang
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Additional information

Received: 9 April 1998 / Accepted: 8 June 1998

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Han, J., Kwon, H., Yim, JB. et al. Effect of IciA protein on the expression of the nrd gene encoding ribonucleoside diphosphate reductase in E. coli . Mol Gen Genet 259, 610–614 (1998). https://doi.org/10.1007/s004380050854

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  • DOI: https://doi.org/10.1007/s004380050854

  • Key wordsnrd
  • Ribonucleoside diphosphate reductase
  • IciA
  • DnaA