Abstract
The suppressor of Hairy-wing [su(Hw)] protein inhibits the function of transcriptional enhancers located distal to the promoter with respect to the location of su(Hw)-binding sites (insulation). Mutations in the modifier of mdg4 [mod(mdg4)] interfere with insulation and enhance the effect of the su(Hw)-binding region inserted in the y 2 mutation by inhibiting the function of regulatory elements located on both sides of the su(Hw)-binding region. From P-M hybrid dysgenic crosses, 21 mutations that suppress the negative effect of the mod(mdg4) 1u1 mutation on the y 2 allele were obtained among 47 000 flies scored. These Su(mg) mutations have a dominant suppressor effect and map to at least 13 different loci. Some of Su(mg) mutations also suppress the effect of mod(mdg4) 1u1 on two other gypsy-induced mutations, sc D1 and ct 6. Most of Su(mg) mutations do not affect the viability or fertility of homozygous flies. We speculate that the Su(mg) genes represent a new family of redundant regulatory genes in Drosophila melanogaster.
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Received: 5 May 1997 / Accepted: 4 July 1997
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Bezborodova, E., Kulikov, A. & Georgiev, P. A new family of genes which, when mutated, suppress the inhibitory effect of the mod(mdg4) 1u1 mutation on y 2 expression in Drosophila melanogaster . Mol Gen Genet 257, 83–90 (1997). https://doi.org/10.1007/s004380050626
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DOI: https://doi.org/10.1007/s004380050626