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RIT2: responsible and susceptible gene for neurological and psychiatric disorders

Molecular Genetics and Genomics volume 293, pages 785–792 (2018)Cite this article

Abstract

RIT2 gene was recently introduced as a susceptibility gene in neurological disorders, a group of major problems in human society affecting millions of people worldwide. Several variants, including single nucleotide polymorphisms and CNVs, have been identified and studied in different populations. In this review, we have summarized the studies relevant to the RIT2 gene and its related disorders, including Parkinson’s disease, schizophrenia, and autism. The protein product of RIT2 is a member of the Ras superfamily that plays important roles in many vital cellular functions, such as differentiation and survival. We have also investigated the protein network of the RIT2 protein and the diseases related to members of this network so as to obtain some clues for future studies by identifying the molecular pathophysiology of neurological disorders and revealing new possible disorders related to RIT2.

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Affiliations

  1. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran

    Yousef Daneshmandpour & Babak Emamalizadeh

  2. Department of Medical Genetics, Semnan University of Medical Sciences, Semnan, Iran

    Hossein Darvish

Authors
  1. Yousef Daneshmandpour
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  2. Hossein Darvish
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  3. Babak Emamalizadeh
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Correspondence to Babak Emamalizadeh.

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Yousef Daneshmandpour declares that he has no conflict of interest. Hossein Darvish declares that he has no conflict of interest. Babak Emamalizadeh declares that he has no conflict of interest.

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Communicated by S. Hohmann.

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Daneshmandpour, Y., Darvish, H. & Emamalizadeh, B. RIT2: responsible and susceptible gene for neurological and psychiatric disorders. Mol Genet Genomics 293, 785–792 (2018). https://doi.org/10.1007/s00438-018-1451-4

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  • DOI: https://doi.org/10.1007/s00438-018-1451-4

Keywords

  • Neurological disorder
  • Neurodegenerative disorder
  • RIT2
  • Ras
  • Parkinson’s disease
  • Autism
  • Bipolar disorder
  • Schizophrenia