Abstract
RNA polymerase II (Pol II) transcribes two classes of RNAs, protein-coding and non-protein-coding (ncRNA) genes. ncRNAs are also synthesized by RNA polymerases I and III (Pol I and III). In humans, the number of ncRNA genes exceeds more than twice that of protein-coding genes. However, the history of studying Pol II-synthesized ncRNA is relatively short. Since early 2000s, important biological and pathological functions of these ncRNA genes have begun to be discovered and intensively studied. And transcription mechanisms of long non-coding RNA (lncRNA) have been recently reported. Transcription of lncRNAs utilizes some transcription factors and mechanisms shared in that of protein-coding genes. In addition, tissue specificity in lncRNA gene expression has been shown. LncRNAs play essential roles in regulating the expression of neighboring or distal genes through different mechanisms. This leads to the implication of lncRNAs in a wide variety of biological pathways and pathological development. In this review, the newly discovered transcription mechanisms, characteristics, and functions of lncRNA are discussed.
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Abbreviations
- ANRIL:
-
Antisense non-coding RNA in the INK4 locus
- ATM:
-
Ataxia telangiectasia mutated
- BACE:
-
B-site APP cleaving enzyme-1
- BACE-AS:
-
B-site APP cleaving enzyme-1- antisense transcript
- CARL:
-
Cardiac apoptosis-related lncRNA
- CTCF:
-
CCCTC-binding factor
- DNMT3:
-
DNA methyltransferase 3
- DNA-PK:
-
DNA-dependent protein kinase
- DSIF:
-
DRB sensitivity-inducing factor
- eRNA:
-
Enhancer RNA
- HSF1:
-
Heat shock factor 1
- HSP70:
-
Heat shock protein 70
- HOTAIR:
-
Hox transcript antisense RNA
- HEK293:
-
Human embryonic kidney 293
- LncRNA:
-
Long non-coding RNA
- MALAT1:
-
Metastasis-associated lung adenocarcinoma transcription 1
- mES:
-
Mouse embryonic stem
- MIAT:
-
Myocardial infarction associated transcript
- MYH7:
-
Myosin heavy gene 7
- NAT:
-
Natural antisense transcript
- NELF:
-
Negative elongation factor
- NcRNA:
-
Non-coding RNA
- PABPN1:
-
Poly(A)-binding protein nuclear 1
- pTEFb:
-
Positive transcription elongation factor b
- Pol II:
-
RNA polymerase II
- SNP:
-
Single nucleotide polymorphism
- TSS:
-
Transcription start site
- TTS:
-
Transcription termination site
- TRIM28:
-
Tripartite motif containing 28
- XIST:
-
X inactivate-specific transcript
- XUT:
-
XRN1 (5′ → 3′ exonuclease)-sensitive unstable transcript
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Acknowledgements
I appreciate my colleagues in the School of Applied Biosciences at Kyungpook National University, D. Taatjes at the University of Colorado, J. Roberts at Cornell University, G. Hu at National Institute of Environmental Health Sciences (NIEHS), and B. Chen and M. Story at the University of Texas Southwestern Medical Center for their support. I thank D. Bunch and R. Baker for their loving encouragement. I also thank Enago for the help with editing manuscript.
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This study was supported by Grants from the Industry-Academic Cooperation Foundation at Kyungpook National University (KNU) to H.B.
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There is no conflict of interest for the enclosed review article.
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Communicated by S. Hohmann.
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Bunch, H. Gene regulation of mammalian long non-coding RNA. Mol Genet Genomics 293, 1–15 (2018). https://doi.org/10.1007/s00438-017-1370-9
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DOI: https://doi.org/10.1007/s00438-017-1370-9