Y-SNP L1034: limited genetic link between Mansi and Hungarian-speaking populations
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Genetic studies noted that the Hungarian Y-chromosomal gene pool significantly differs from other Uralic-speaking populations. Hungarians show very limited or no presence of haplogroup N-Tat, which is frequent among other Uralic-speaking populations. We proposed that some genetic links need to be observed between the linguistically related Hungarian and Mansi populations.This is the first attempt to divide haplogroup N-Tat into subhaplogroups by testing new downstream SNP markers L708 and L1034. Sixty Northern Mansi samples were collected in Western Siberia and genotyped for Y-chromosomal haplotypes and haplogroups. We found 14 Mansi and 92 N-Tat samples from 7 populations. Comparative results showed that all N-Tat samples carried the N-L708 mutation. Some Hungarian, Sekler, and Uzbek samples were L1034 SNP positive, while all Mongolians, Buryats, Khanty, Finnish, and Roma samples yielded a negative result for this marker. Based on the above, L1034 marker seems to be a subgroup of N-Tat, which is typical for Mansi and Hungarian-speaking ethnic groups so far. Based on our time to most recent common ancestor data, the L1034 marker arose 2,500 years before present. The overall frequency of the L1034 is very low among the analyzed populations, thus it does not necessarily mean that proto-Hungarians and Mansi descend from common ancestors. It does provide, however, a limited genetic link supporting language contact. Both Hungarians and Mansi have much more complex genetic population history than the traditional tree-based linguistic model would suggest.
KeywordsY haplogroup N-L1034 and L708 Hungarian-speaking populations West Siberian Mansi population Human demographic history
The authors would like to thank all of the Mansi and Finnish donors for their involvement in this study. We say special thanks to Pasi Tuominen, Ambassador of Finland to Hungary, Réka Hernádi and Johanna Nurmikari, leading Finnish teachers for involving the Finnish community living in Hungary in the project. We also give special thanks to the Ministry of Human Resources (Hungary), and the Reguly Association (organization for specialists of Finno-Ugric Studies) for the support of organizing the expedition to Western Siberia. Furthermore, we are indebted to Bálint Kacsóh, Nándor Dreisziger, Imre Bokor, Levente Molnár, and Anikó Szilágyi, who also supported our project financially. We would like, especially, to thank Dr. Eva Susa (General Director of the Network of Forensic Science Institutes) for her support and Bettyjean Sigethy for the English editing and also thank all sample donors and laboratory assistants.
Conflict of interest
The authors declare no conflict of interest.
- Balanovsky OP (2012) Измeнчивocть гeнoфoндa в пpocтpaнcтвe и вpeмeни: cинтeз дaнныx o гeнoгeoгpaфии митxoндpиaльнoй ДHК и Y-xpoмocoмы Aвтopeфepaт диccepтaции нa coиcкaниe yчeнoй cтeпeни дoктopa биoлoгичecкиx нayк MocквaGoogle Scholar
- Chernetsov, VN, Mosinskaya, VI. (B.H. Чepнeцoв, B.И. Moшинcкaя) (1954) B пoиcкax дpeвнeй poдины yгopcкиx нapoдoв. In: Пo cлeдaм дpeвниx кyльтyp. Oт Boлги дo Tиxoгo oкeaнa. Moszkva, Nauka 163–192Google Scholar
- Csányi B, Bogácsi-Szabó E, Gy Tömöry, Czibula A, Priskin K, Csősz A, Mende B, Langó B, Csete K, Zsolnai A, Conant EK, Downes CS, Raskó I (2008) Y-chromosome analysis of ancient Hungarian and two modern Hungarian-speaking populations from the Carpathian Basin. Ann Hum Genet 72:519–534PubMedCrossRefGoogle Scholar
- Dulik MC, Zhadanov SI, Osipova LP, Askapuli A, Gau L, Gokcumen O, Samara Rubinstein S, Theodore G (2012) Mitochondrial DNA and Y chromosome variation provides evidence for a recent common ancestry between Native Americans and Indigenous Altaians. Am J Hum Genet 90(2):229–246PubMedCentralPubMedCrossRefGoogle Scholar
- Fodor I (1975) Verecke Híres útján. Gondolat, Budapest, HungaryGoogle Scholar
- Hajdú P (1975) A rokonság nyelvi háttere in Uráli népek page. Corvina, Budapest, p 36Google Scholar
- Köpeczi B (ed) (2001) History of Transylvania, Vol I. Columbia University Press, New YorkGoogle Scholar
- Kornienko IV, Bondarenko EV, Mikhalkovich LS, Moliarchuk BA, Kotova EN (2009) Polymorphism of Y-chromosomal microsatellites in Russian population from Southern Federal District of the Russian Federation. Genetika (Russian) 45(1):132–136Google Scholar
- Myres NM, Rootsi S, Lin AA, Järve M, King RJ, Kutuev I, Cabrera VM, Khusnutdinova EK, Pshenichnov A, Yunusbayev B, Balanovsky O, Balanovska E, Rudan P, Baldovic M, Herrera RJ, Chiaroni J, Di Cristofaro J, Villems R, Kivisild T, Underhill PA (2011) A major Y-chromosome haplogroup R1b Holocene era founder effect in Central and Western Europe. Eur J Hum Genet 19(1):95–101PubMedCentralPubMedCrossRefGoogle Scholar
- Roewer L, Willuweit S, Krüger C, Nagy M, Rychkov S, Morozowa I, Naumova O, Schneider Y, Zhukova O, Stoneking M, Nasidze I (2008) Analysis of Y chromosome STR haplotypes in the European part of Russia reveals high diversities but non-significant genetic distances between populations. Int J Legal Med 122(3):219–223PubMedCentralPubMedCrossRefGoogle Scholar
- Rootsi S, Zhivotovsky LA, Baldovic M, Kayser M, Kutuev IA, Khusainova R, Bermisheva MA, Gubina M, Fedorova SA, Ilumäe AM, Khusnutdinova EK, Voevoda MI, Osipova LP, Stoneking M, Lin AA, Ferak V, Parik J, Kivisild T, Underhill PA, Villems R (2007) A counter-clockwise northern route of the Y-chromosome haplogroup N from Southeast Asia towards Europe. Eur J Hum Genet 15(2):204–211PubMedCrossRefGoogle Scholar
- Schneider S, Roessli D, Excoffier L (2000) Arlequin: a software for population genetics data analysis. Ver 2.000, Genetics and Biometry Lab, Deptartment of Anthropology, University of GenevaGoogle Scholar
- Tambets K, Rootsi S, Kivisild T, Help H, Serk P, Loogväli EL, Tolk HV, Reidla M, Metspalu E, Pliss L, Balanovsky O, Pshenichnov A, Balanovska E, Gubina M, Zhadanov S, Osipova L, Damba L, Voevoda M, Kutuev I, Bermisheva M, Khusnutdinova E, Gusar V, Grechanina E, Parik J, Pennarun E, Richard C, Chaventre A, Moisan JP, Barác L, Pericić M, Rudan P, Terzić R, Mikerezi I, Krumina A, Baumanis V, Koziel S, Rickards O, De Stefano GF, Anagnou N, Pappa KI, Michalodimitrakis E, Ferák V, Füredi S, Komel R, Beckman L, Villems R (2004) The western and eastern roots of the Saami—the story of genetic “outliers” told by mitochondrial DNA and Y chromosomes. Am J Hum Genet 74:661–682PubMedCentralPubMedCrossRefGoogle Scholar
- Underhill PA, Myres NM, Rootsi S, Metspalu M, Zhivotovsky LA, King RJ, Lin AA, Chow CE, Semino O, Battaglia V, Kutuev I, Järve M, Chaubey G, Ayub Q, Mohyuddin A, Mehdi SQ, Sengupta S, Rogaev EI, Khusnutdinova EK, Pshenichnov A, Balanovsky O, Balanovska E, Jeran N, Augustin DH, Baldovic M, Herrera RJ, Thangaraj K, Singh V, Singh L, Majumder P, Rudan P, Primorac D, Villems R, Kivisild T (2010) Separating the post-glacial coancestry of European and Asian Y chromosomes within haplogroup R1a. Eur J Hum Genet 18(4):479–484PubMedCentralPubMedCrossRefGoogle Scholar
- Zhivotovsky LA, Underhill PA, Cinnioğlu C, Kayser M, Morar B, Kivisild T, Scozzari R, Cruciani F, Destro-Bisol G, Spedini G, Chambers GK, Herrera RJ, Yong KK, Gresham D, Tournev I, Feldman MW, Kalaydjieva L (2004) The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time. Am J Hum Genet 74:50–61PubMedCentralPubMedCrossRefGoogle Scholar