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Modulation of gene expression by alloimmune networks following murine heart transplantation

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Abstract

The objective of our study was to analyze gene expression profiles in a complex in vivo model of solid organ transplantation, and to investigate the effects of single-gene deletions on alloimmunity. Using algorithms to generate dendrograms and self-organizing maps, we differentiated the alloimmune profiles of 16 transgenic knockout mouse strains, and identified subsets of genes that correlate with the duration of graft survival and provide candidates for prognostic and diagnostic indicators following transplantation in our model system.

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Acknowledgements

All work described in this paper has been carried out in compliance with the current laws governing genetic experimentation in the USA. We thank M. Sayegh, Y. Colson and B. Schaub for critical review of the manuscript, H. He and M. Xu for technical support. This work was supported by grants from the American Heart Association, Arthritis Foundation, and National Institutes of Health (AI44085) to D. L. Perkins

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Authors and Affiliations

  1. Laboratory of Molecular Immunology, Renal Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, PBB 170, Boston, MA 02115, USA

    K. Christopher, T. F. Mueller & D. L. Perkins

  2. Laboratory of Molecular Immunology, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA

    Y. Liang

  3. Pulmonary Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA

    P. W. Finn

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  1. K. Christopher
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  2. T. F. Mueller
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  3. Y. Liang
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  4. P. W. Finn
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  5. D. L. Perkins
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Corresponding author

Correspondence to D. L. Perkins.

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Communicated by C. P. Hollenberg

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Christopher, K., Mueller, T.F., Liang, Y. et al. Modulation of gene expression by alloimmune networks following murine heart transplantation. Mol Genet Genomics 271, 687–696 (2004). https://doi.org/10.1007/s00438-004-1013-9

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  • DOI: https://doi.org/10.1007/s00438-004-1013-9

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